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Extraction of bioactive compounds from Curcuma longa L. using deep eutectic solvents: in vitro and in vivo biological activities

2021Journal article Open access
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dc.contributor.authorOliveira, Grazielle
dc.contributor.authorMarques, Caroline
dc.contributor.authorOliveira, Anielle
dc.contributor.authorSantos, Amanda de Almeida
dc.contributor.authorAmaral, Wanderlei
dc.contributor.authorIneu, Rafael P.
dc.contributor.authorLeimann, Fernanda Vitória
dc.contributor.authorPeron, Ana Paula
dc.contributor.authorIgarashi-Mafra, Luciana
dc.contributor.authorMafra, Marcos R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T11:27:45Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T11:27:45Z
dc.date.issued2021
dc.description.abstractIn this work, deep eutectic solvents (DES-based menthol and cholinium chloride) and the ethanol, temperature, and times were selected to extract bioactive compounds from the rhizome, leaves, and flowers Curcuma longa L., using ultrasound-assisted extraction. Analyzes antioxidant, flavonoids, antimicrobial, chelation Fe2+, inhibition of the cholinesterase's enzymes, cytotoxicity, and genotoxicity in Allium cepa cells were performed. The extracts showed results of iron chelation and antibacterial. Curcuma flowers and leaves' extracts inhibited food spoilage bacteria with values above 45%, with substantial iron-chelating activity above 50%. Extracts obtained by DES based on menthol and lactic acid exhibited a high percentage of inhibition of acetyl and butyryl cholinesterase. In contrast, flower extracts obtained by menthol and acetic acid showed low inhibition of cholinesterase enzyme activity. No extract showed cytotoxicity and genotoxicity. Biological activities showed a high potential for the application of these extracts in the food and pharmaceutical industries.en_EN
dc.description.sponsorshipThis study was financed by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) – Finance Code 001. The authors thank both CAPES for the financial support, the Federal University of Paraná (UFPR) and the Federal University of Technology - Paraná (UTFPR), Labmulti-CM (UTFPR) for the technical support provided. M. R. Mafra and L. Igarashi-Mafra are grateful to the Brazilian National Council for Scientific and Technological Development (CNPq - Grant 310182/2018-2 and 308517/2018-0, respectively).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationOliveira, Grazielle; Marques, Caroline; de Oliveira, Anielle; de Almeida dos Santos, Amanda; do Amaral, Wanderlei; Ineu, Rafael Porto; Leimann, Fernanda Vitória; Peron, Ana Paula; Igarashi-Mafra, Luciana; Mafra, Marcos R. (2021). Extraction of bioactive compounds from Curcuma longa L. using deep eutectic solvents: In vitro and in vivo biological activities. Innovative Food Science and Emerging Technologies. ISSN 1466-8564. 70, p. 1-9en_EN
dc.identifier.doi10.1016/j.ifset.2021.102697en_EN
dc.identifier.issn1466-8564
dc.identifier.urihttp://hdl.handle.net/10198/24335
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectAntibacterialen_EN
dc.subjectAntioxidanten_EN
dc.subjectCellular level toxicityen_EN
dc.subjectCholinesteraseen_EN
dc.subjectIron-chelatingen_EN
dc.titleExtraction of bioactive compounds from Curcuma longa L. using deep eutectic solvents: in vitro and in vivo biological activitiesen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameLeimann
person.givenNameFernanda Vitória
person.identifier.ciencia-id8F10-A04D-FC0D
person.identifier.orcid0000-0001-6230-9597
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublicationb1102a0b-38dc-4caa-baed-ad52ccd9b230
relation.isAuthorOfPublication.latestForDiscoveryb1102a0b-38dc-4caa-baed-ad52ccd9b230

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