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New therapeutic approaches to chronic kidney disease

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dc.contributor.authorNogueira, António José M.
dc.contributor.authorVala, Helena
dc.contributor.authorNóbrega, Carmen
dc.contributor.authorPires, Carlos André
dc.contributor.authorColaço, Bruno Jorge
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorPires, Maria João
dc.date.accessioned2019-11-11T15:15:00Z
dc.date.available2019-11-11T15:15:00Z
dc.date.issued2018
dc.description.abstractThe main research goal in patients with chronic kidney disease (CKD) is the development of new therapeutic approaches capable of slowing down the progression to end-stage renal disease. The aim of this work was to evaluate the effects of long-term administration of chaetomellic acid A (CAA), which selectively blocks H-Ras farnesylation, on chronic kidney lesions in 5/6 nephrectomized Wistar rats, an animal model of chronic renal disease. Materials and Methods: Sixty male Wistar rats were sham-operated (SO) or submitted to 5/6 nephrectomy (RMR). One week after surgery, surviving animals were distributed into four groups: SO–SO rats receiving no treatment (n = 13); SO+CAA–SO rats receiving CAA treatment (n = 13); RMR–RMR rats receiving no treatment (n = 14); RMR+CAA–RMR rats receiving CAA treatment (n = 13). CAA was administered intraperitoneally three times a week for 6 months. Renal fibrosis was evaluated by ultrasonography and histopathological analysis. All experimental procedures followed the European (European Directive 2010/63/EU) and National (Decree-Law 113/2013) legislation on the protection of the animals used for scientific purposes. Results: The kidneys of the RMR animals treated with CAA showed a significant decrease in medullary echogenicity (P <0.05) compared with the RMR rats that received no treatment. Glomerulosclerosis and arteriolosclerosis scores were significantly lower (P <0.001) in the RMR+CAA group when compared with the RMR group. Conclusion: These data suggest that pharmacological inhibition of H-Ras proteins activation may be a future strategy in the prevention of end-stage renal disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNogueira, António José M.; Vala, Helena; Nóbrega, Carmen; Pires, Carlos André; Colaço, Bruno; Oliveira, Paula; Pires, Maria João (2018). New therapeutic approaches to chronic kidney disease. Journal of Comparative Pathology. ISSN 1532-3129. 158, special number, p. 127pt_PT
dc.identifier.doi10.1016/j.jcpa.2017.10.098pt_PT
dc.identifier.issn1532-3129
dc.identifier.urihttp://hdl.handle.net/10198/19798
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectChaetomellic acid AIntroduction: Tpt_PT
dc.subject5/6 nephrectomized ratspt_PT
dc.titleNew therapeutic approaches to chronic kidney diseasept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.startPage127pt_PT
oaire.citation.titleJournal of Comparative Pathologypt_PT
oaire.citation.volume158pt_PT
person.familyNameNogueira
person.givenNameAntónio José M.
person.identifier.ciencia-id8A11-794E-36BD
person.identifier.orcid0000-0001-8912-7355
person.identifier.scopus-author-id55865568268
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication648209a2-eec9-4bec-975a-32673e41b95c
relation.isAuthorOfPublication.latestForDiscovery648209a2-eec9-4bec-975a-32673e41b95c

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