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3D manufacturing of intracranial aneurysm biomodels for flow visualizations: low cost fabrication processes

2020Journal article Open access
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dc.contributor.authorSouza, Andrews Victor Almeida
dc.contributor.authorSouza, Mauren S.
dc.contributor.authorPinho, Diana
dc.contributor.authorAgujetas, Rafael
dc.contributor.authorFerrera, Conrado
dc.contributor.authorLima, Rui A.
dc.contributor.authorPuga, Hélder Fernandes
dc.contributor.authorRibeiro, J.E.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-06-22T10:18:33Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-06-22T10:18:33Z
dc.date.issued2020
dc.description.abstractThere is a continuous search for better and more complete in vitro models with mechanical properties closer to in vivo conditions. In this work a manufacturing process, based on a lost core casting technique, is herein reported to produce aneurysm biomodels to perform experimental hemodynamic studies. By us- ing real artery images combined with a lost core casting technique, three materials were tested: paraffin, beeswax and glycerin-based soap. All in vitro biomodels were compared according to their transparency and final structure. Additionally, comparisons between experimental and numerical flow studies were also performed. The results have shown that the biomodels produced with beeswax and glycerine-based soap were the most suitable in vitro models to perform direct flow visualizations of particulate blood analogue fluids. The biomodels proposed in this works, have the potential to provide further insights into the complex blood flow phenomena happening at different kinds of pathologies and answer to important hemodynamics questions that otherwise cannot be tackled with the existing in vitro models.
dc.description.sponsorshipThis work has been supported by FCT –Fundação para a Ciência e Tecnologia within the R&D Units Project Scope: UIDB/0 0319/2020 , UIDB/04077/2020 , UIDB/0 0690/2020 and NORTE-01-0145-FEDER-030171 , funded by COMPETE2020, NORTE 2020, PORTUGAL 2020 and FEDER, R.A and C.F.acknowledge the support of Junta de Extremadura through Grants GR18175 and IB16119 (partially financed by FEDER) This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 798014. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 828835 .
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSouza, A.; Souza, M. S.; Pinho, D.; Agujetas, R.; Ferrera, C.; Lima, R.; Puga, H.; Ribeiro, J. (2020). 3D manufacturing of intracranial aneurysm biomodels for flow visualizations: low cost fabrication processes. Mechanics Research Communications. ISSN 0093-6413. 107, p. 1-8en_EN
dc.identifier.doi10.1016/j.mechrescom.2020.103535en_EN
dc.identifier.issn0093-6413
dc.identifier.urihttp://hdl.handle.net/10198/22313
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationDeveloping an Artificial Intestine for the sustainable farming of healthy fish
dc.subjectBiomodelsen_EN
dc.subjectComputational fluid dynamicsen_EN
dc.subjectExperimental mechanicsen_EN
dc.subjectIntracranial aneurysmen_EN
dc.subjectManufacturingen_EN
dc.title3D manufacturing of intracranial aneurysm biomodels for flow visualizations: low cost fabrication processesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDeveloping an Artificial Intestine for the sustainable farming of healthy fish
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/828835/EU
oaire.fundingStreamH2020
person.familyNamePinho
person.familyNameRibeiro
person.givenNameDiana
person.givenNameJ.E.
person.identifierR-000-6Y8
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-id0F15-FB62-29DB
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0001-6300-148X
person.identifier.ridG-3839-2018
person.identifier.scopus-author-id25638652400
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication02bf2dd9-33ed-4d87-b61d-ca39c51f8451
relation.isAuthorOfPublicationc90169e6-7889-4270-a096-35b98c75f9f9
relation.isAuthorOfPublication.latestForDiscovery02bf2dd9-33ed-4d87-b61d-ca39c51f8451
relation.isProjectOfPublication45ee6fd8-5246-4ee0-ab83-743d5123a0e8
relation.isProjectOfPublication.latestForDiscovery45ee6fd8-5246-4ee0-ab83-743d5123a0e8

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