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Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine

2023Journal article Open access
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dc.contributor.authorEssoh, Anyse P.
dc.contributor.authorCassiano, Gustavo Capatti
dc.contributor.authorMandim, Filipa
dc.contributor.authorBarros, Lillian
dc.contributor.authorGomes, Isildo
dc.contributor.authorMedeiros, Márcia Melo
dc.contributor.authorMoura, Monica B.M.V.
dc.contributor.authorCravo, Pedro V.L.
dc.contributor.authorRomeiras, Maria M.
dc.date.accessioned2024-01-03T11:08:11Z
dc.date.available2024-01-03T11:08:11Z
dc.date.issued2023
dc.description.abstractMedicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal purposes. The present study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde (i.e., Artemisia gorgonum, Lavandula rotundifolia, Sideroxylon marginatum, and Tamarix senegalensis). Traditional preparations of these medicinal plants, namely aqueous extracts (infusions) and ethanolic extracts, were tested against both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains using the SYBR Green detection method. The in vitro cytotoxicity was evaluated in Caco-2 and PLP2 cells using a sulforhodamine B colorimetric assay. An ethanolic extract of A. gorgonum and infusions of T. senegalensis exhibited high antiplasmodial activities (EC50 < 5 g/mL) without cytotoxicity (GI50 > 400 g/mL). Extracts of L. rotundifolia and S. marginatum exhibited moderate activities, with EC50 values ranging from 10–30 g/mL. The A. gorgonum ethanolic extract showed activity toward early ring stages, and parasites treated with the T. senegalensis infusions progressed to the early trophozoite stage, although did not develop further to the late trophozoite or schizont stages. Antimalarial activities and the lack of cytotoxicity of the extracts are reported in the present study and support previous claims by traditional practitioners for the use of these plants against malaria while suggesting their ethnopharmacological usefulness as future antimalarials.pt_PT
dc.description.sponsorshipThis research was funded by the Fundação para a Ciência e Tecnologia (Project ref: PTDC/SAU-PAR/28459/2017) and FCT/AgaKhan Development Network (AKDN) through the project CVAgrobiodiversity/333111699.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEssoh, Anyse P.; Cassiano, Gustavo Capatti; Mandim, Filipa; Barros, Lillian; Gomes, Isildo; Medeiros, Márcia Melo; Moura, Mónica; Cravo, Pedro V.L.; Romeiras, Maria M. (2023). Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine. Plants. eISSN 2223-7747. 12:4, p. 1-12pt_PT
dc.identifier.doi10.3390/plants12040963pt_PT
dc.identifier.eissn2223-7747
dc.identifier.urihttp://hdl.handle.net/10198/29048
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTropical plantspt_PT
dc.subjectTraditional medicinept_PT
dc.subjectMalariapt_PT
dc.subjectEthnopharmacologypt_PT
dc.subjectWest Africapt_PT
dc.titleAntimalarial and cytotoxic activity of native plants used in cabo verde traditional medicinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PAR%2F28459%2F2017/PT
oaire.citation.endPage12pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePlantspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameMandim
person.familyNameBarros
person.givenNameFilipa
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01
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