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Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells

2023Journal article Open access
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dc.contributor.authorMarques, Mário Pedro
dc.contributor.authorNeves, Beatriz Guapo
dc.contributor.authorVarela, Carla
dc.contributor.authorZuzarte, Mónica
dc.contributor.authorGoncalves, Ana Cristina
dc.contributor.authorDias, Maria Inês
dc.contributor.authorAmaral, Joana S.
dc.contributor.authorBarros, Lillian
dc.contributor.authorMagalhães, Mariana
dc.contributor.authorCabral, Célia
dc.date.accessioned2018-02-21T16:27:17Z
dc.date.available2018-02-21T16:27:17Z
dc.date.issued2023
dc.description.abstractLavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Coa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional uses, these aromatic plants are still undervalued, and literature regarding their bioactivity, especially anticancer, is scarce. In this work, the morphology of secretory structures was assessed by scanning electron microscopy (SEM), and the composition of essential oils (EOs) was characterized by gas chromatography-mass spectrometry (GC-MS). The study proceeded with cytotoxic evaluation of EOs in tumor and non-tumor cells with the cell death mechanism explored in glioblastoma (GB) cells. L. pedunculata EO presented the most pronounced cytotoxic/antiproliferative activity against tumor cells, with moderate cytotoxicity against non-tumor cells. Whereas, M. cervina EO exhibited a slightly lower cytotoxic effect against tumor cells and did not affect the viability of non-tumor cells. Meanwhile, T. mastichina EO did not induce a strong cytotoxic effect against GB cells. L. pedunculata and M. cervina EOs lead to cell death by inducing apoptosis in a dose-dependent manner. The present study suggests that L. pedunculata and M. cervina EOs have a strong cytotoxic and antiproliferative potential to be further studied as efficient antitumor agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarques, Mário P.; Neves, Beatriz Guapo; Varela, Carla; Zuzarte, Mónica; Goncalves, Ana Cristina; Dias, Maria Inês; Amaral, Joana S.; Barros, Lillian; Magalhães, Mariana; Cabral, Célia (2023). Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells. Pharmaceutics. eISSN 1999-4923. 15:2, p. 1-18pt_PT
dc.identifier.doi10.3390/pharmaceutics15020341
dc.identifier.eissn1999-4923
dc.identifier.urihttp://hdl.handle.net/10198/15905
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEssential oilspt_PT
dc.subjectLavandula pedunculatapt_PT
dc.subjectMentha cervinapt_PT
dc.subjectThymus mastichina subsp. mastichinapt_PT
dc.subjectCôa Valleypt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectGlioblastoma
dc.titleEssential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titlePharmaceuticspt_PT
person.familyNameDias
person.familyNameAmaral
person.familyNameBarros
person.givenNameMaria Inês
person.givenNameJoana S.
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id5319-7DE8-BEDA
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-3648-7303
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublication42be2cf4-adc4-4e7f-ac60-7aab515b38cd
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01

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