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Chemical characterization, bioactivity and toxicity of european flora plant extracts in search for potential natural origin preservatives

2023Artigo científico Acesso aberto
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dc.contributor.authorDeus, Breno Martins de
dc.contributor.authorFernandes, Conceição
dc.contributor.authorMolina, Adriana K.
dc.contributor.authorXavier, Virginie
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorMandim, Filipa
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2023-05-10T09:16:39Z
dc.date.available2023-05-10T09:16:39Z
dc.date.issued2023
dc.description.abstractConsumer demand for natural and healthier products has led to an increasing interest in the bioactive and therapeutic properties of plant extracts. In this study, we evaluated the phenolic compounds profile, bioactivities, and toxicities of plant extracts from eight European flora species, including Calendula officinalis L., Calluna vulgaris (L.) Hull, Hippophae rhamnoides L., Juglans regia L., Mentha cervina L., Rubus idaeus L., Sambucus nigra L., and Vitis vinifera L. The aim was to identify potential preservatives of natural origin. Phenolic compounds were identified by HPLC-DAD-ESI-MS. Caffeic acid derivatives, ellagitannins, flavonols, and flavones were the major phenolic compounds identified. The total phenolic content varied from 16.0 & PLUSMN; 0.2 (V. vinifera) to 123 & PLUSMN; 2 mg/g (H. rhamnoides) of dry extract. All extracts showed antioxidant potential and exhibited activity against some of the microorganisms tested. S. nigra showed the highest activity in the inhibition of oxidative hemolysis (OxHLIA) assay and H. rhamnoides, notably, had the lowest IC50 values in TBARS and DPPH assays, as well as the lowest minimum inhibitory concentration (MIC) values. Regarding in vitro cytotoxicity, in tumor and non-tumor cell lines, although some extracts revealed toxicity against normal cells, it was found that the samples C. vulgaris, V. vinifera and R. idaeus might be used against tumor cells since the active concentration is much lower than the one causing toxicity. In vivo acute toxicity tests using Artemia franciscana suggest low toxicity for most extracts, with LC50 > 400 mg/L. These results showed the potential of the studied extracts as natural preservatives, given their richness in compounds with bioactive properties, highlight their potential value to the production chain.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020). National funding was given by FCT, P.I., through the institutional scientific employment programcontracts of L. Barros and S.A. Heleno, and the PhD grant of F. Mandim (SFRH/BD/146614/2019), and we also thank the MICINN for the Juan de la Cierva Formación contract for T.C.S.P. Pires (FJC20120-045405-I). This manuscript has received funding from the Bio Based Industries Joint Undertaking (JU) under grant agreement No 887917 BeonNAT.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDeus, Breno Martins de; Fernandes, Conceição; Molina, Adriana K.; Xavier, Virginie; Pires, Tânia C.S.P.; Mandim, Filipa; Heleno, Sandrina A.; Finimundy, Tiane C.; Barros, Lillian (2023). Chemical characterization, bioactivity and toxicity of european flora plant extracts in search for potential natural origin preservatives. Plants. eISSN 2223-7747. 12:15, p. 1-18pt_PT
dc.identifier.doi10.3390/plants12152784
dc.identifier.eissn2223-7747
dc.identifier.urihttp://hdl.handle.net/10198/28263
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhenolic compounds
dc.subjectPlant extracts
dc.subjectNatural preservatives
dc.subjectBioactivity
dc.subjectToxicity
dc.subjectArtemia franciscana
dc.subjectEuropean flora
dc.titleChemical characterization, bioactivity and toxicity of european flora plant extracts in search for potential natural origin preservativespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titlePlantspt_PT
person.familyNameFernandes
person.familyNameMolina
person.familyNameXavier
person.familyNamePires
person.familyNameMandim
person.familyNameHeleno
person.familyNameFinimundy
person.familyNameBarros
person.givenNameConceição
person.givenNameAdriana K.
person.givenNameVirginie
person.givenNameTânia C.S.P.
person.givenNameFilipa
person.givenNameSandrina A.
person.givenNameTiane C.
person.givenNameLillian
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person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0003-3516-0795
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridQ-2842-2018
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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