Publication
Novel Hydroxy-9H-xanthen-9-ones derivatives: synthesis and bioactive properties
| dc.contributor.author | Santos, Clementina M.M. | |
| dc.contributor.author | Silva, Artur | |
| dc.contributor.author | Cavaleiro, José | |
| dc.date.accessioned | 2011-09-26T08:56:49Z | |
| dc.date.available | 2011-09-26T08:56:49Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | 9H-Xanthen-9-ones commonly referred as xanthones are a large group of natural heterocyclic compounds with significant bioactive properties (e.g. anti-inflammatory, antibacterial, antimalarial, cytotoxicity and radical scavenging activity).1 In order to explore some of these biological assessments, we developed two methodologies for the synthesis of novel hydroxylated 2,3-diarylxanthone derivatives. The first synthetic route is based on the Heck reaction of the 3-bromochromone 2 followed by aldol condensation and electrocyclisation/oxidation processes to afford the 2,3-diaryl-9H-xanthen-9-ones 1. An efficient and more general approach is the Heck reaction of 3-bromo-2-styrylchromones 3 with styrenes as olefins followed by the in situ electrocyclisation/oxidation processes.2 Pharmacological studies involving the hydroxy-9H-xanthen-9-ones 1,3 which are obtained after cleavage of the methyl group, will also be presented and discussed. | por |
| dc.identifier.citation | Santos, Clementina M.M.; Silva, Artur; Cavaleiro, José (2011). Novel Hydroxy-9H-xanthen-9-ones derivatives: synthesis and bioactive properties. In 23rd Internacional Congress on Heterocyclic Chemistry. Glasgow | por |
| dc.identifier.uri | http://hdl.handle.net/10198/6162 | |
| dc.language.iso | eng | por |
| dc.title | Novel Hydroxy-9H-xanthen-9-ones derivatives: synthesis and bioactive properties | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Glasgow, Escócia | por |
| oaire.citation.title | 23rd International Congress on Heterocyclic Chemistry | por |
| person.familyName | Santos | |
| person.givenName | Clementina M.M. | |
| person.identifier.ciencia-id | 9018-DB9C-C590 | |
| person.identifier.orcid | 0000-0003-4380-7990 | |
| person.identifier.scopus-author-id | 7201458663 | |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |
| relation.isAuthorOfPublication | 64f662b6-775d-4ea0-bfd7-f527af0ac1a0 | |
| relation.isAuthorOfPublication.latestForDiscovery | 64f662b6-775d-4ea0-bfd7-f527af0ac1a0 |