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Phenolic compounds and bioactive properties of Ruscus aculeatus L. (asparagaceae): the pharmacological potential of an underexploited subshrub

2021Artigo científico Acesso aberto
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dc.contributor.authorRodrigues, Joana P.B.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPereira, Carla
dc.contributor.authorPires, Tânia C.S.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T12:12:44Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T12:12:44Z
dc.date.issued2021
dc.description.abstractRuscus aculeatus L. is a subshrub used in traditional medicine in different parts of the world, namely in Europe and the Iberian Peninsula. According to reported folk knowledge, the aerial parts are mainly used as diuretics and the underground organs are used for the treatment of disorders of the urinary system and as a laxative. In this work, the aerial part and the roots and rhizomes of R. aculeatus were chemically characterized with regard to the content of phenolic compounds and bioactive properties. Aqueous (infusions and decoctions) preparations and hydroethanolic extracts from the two mentioned parts of the plant were prepared. Nine phenolic compounds were detected in all the extracts. Apigenin-C-hexoside-C-pentoside isomer II was the major compound in aqueous extracts and, in the hydroethanolic extract was quercetin-O-deoxyhexoside-hexoside followed by apigenin-C-hexoside-C-pentoside isomer II. All extracts revealed antioxidant activity and potential to inhibit some of the assayed bacteria; aqueous extracts of the aerial part and infusions of roots and rhizomes did not show cytotoxic effects on a non-tumor primary cell culture. This preliminary study provides suggestions of the biological potential associated with the empirical uses and knowledge of this species, in particular its bioactivities.en_EN
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through the national funds FCT/MCTES to CIMO (UIDB/00690/2020) and national funding by FCT, P.I., through the institutional scientific employment program contract for L. Barros, A. Fernandes, M.I. Dias, C. Pereira, and R.C. Calhelha. The authors are also grateful to FEDER-Interreg España-Portugal program for financial support through the project TRANSCoLAB 0612_TRANS_CO_LAB_2_P and to European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project Norte-01-0145-FEDER- 000042: GreenHealth.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationRodrigues, Joana P.B.; Fernandes, Ângela; Dias, Maria Inês; Pereira, Carla; Pires, Tânia C.S.P.; Calhelha, Ricardo C.; Carvalho, Ana Maria; Ferreira, Isabel C.F.R.; Barros, Lillian (2021). Phenolic compounds and bioactive properties of Ruscus aculeatus L. (asparagaceae): the pharmacological potential of an underexploited subshrub. Molecules. ISSN 1420-3049. 26:7, p. 1-13en_EN
dc.identifier.doi10.3390/molecules26071882en_EN
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/24369
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.subjectAerial parten_EN
dc.subjectBioactivitiesen_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectRoots and rhizomesen_EN
dc.subjectRuscus aculeatus L.en_EN
dc.titlePhenolic compounds and bioactive properties of Ruscus aculeatus L. (asparagaceae): the pharmacological potential of an underexploited subshruben_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
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person.givenNameJoana P. B.
person.givenNameÂngela
person.givenNameMaria Inês
person.givenNameCarla
person.givenNameTânia C.S.P.
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.givenNameLillian
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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