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Wild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteria

2014Journal article Open access
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dc.contributor.authorAlves, Maria José
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorLourenço, Inês
dc.contributor.authorCastro, Ana
dc.contributor.authorPereira, Liliana
dc.contributor.authorMartins, Anabela
dc.contributor.authorPintado, Manuela
dc.date.accessioned2015-09-09T14:17:05Z
dc.date.available2015-09-09T14:17:05Z
dc.date.issued2014
dc.description.abstractThe main objective of the present work was to evaluate the capacity of wild mushroom extracts to potentiate the action of standard antibiotics, through synergisms that allow a decrease in their therapeutic doses and ultimately contribute to the reduction of resistances. Methods and Results: Wild mushroom extracts were applied to different multi-resistant microorganisms (Escherichia coli, Extended-spectrum beta-lactamase-producing (ESBL) Escherichia coli and Methicillin-resistant Staphylococcus aureus (MRSA), combined with commercial antibiotics (Penicillin, Ampicillin, Amoxicillin/Clavulanic acid, Cefoxitin, Ciprofloxacin, Cotrimoxazol, Levofloxacin). Microdilution method was used to determine minimum inhibitory concentrations (MICs). The results obtained showed higher synergistic effects against MRSA than against E. coli. Mycena rosea and Fistulina hepatica were the best extracts for synergistic effects against MRSA. The efficiency of Russula delica extract against E. coli 1 (resistant to Ampicillin, Ciprofloxacin and Trimethoprim/Sulfasoxazole) and E. coli 2 (resistant to Amoxicillin/Clavulanic acid and Ampicillin) was higher than that of Leucopaxillus giganteus extract; nevertheless the latter extract exhibited better synergistic effects against ESBL E. coli. Conclusions: This study shows that, similarly to plants, some mushroom extracts can potentiate the action of antibiotics extensively used in clinical practice for Gram-positive or Gram-negative bacteria, with positive action even against multi-resistant bacteria. Significance and Impact of the Study: Mushroom extracts could decrease therapeutic doses of standard antibiotics and reduce microorganism’s resistance to those drugs.por
dc.description.sponsorshipThe authors are grateful to Fundação para a Ciência e a Tecnologia (FCT, Portugal) and COMPETE/QREN/EU for financial support to this work (research project PTDC/AGR-ALI/110062/2009; strategic projects PEst-OE/ AGR/UI0690/2011 and PEst-OE/EQB/LA0016/2011). They also thank to CHTMAD – Hospital Center of Tr as-os- Montes e Alto Douro and Siemens for all the support.por
dc.identifier.citationAlves, Maria José; Ferreira, Isabel C.F.R.; Lourenço, Inês; Castro, Ana; Pereira, Liliana; Martins, Anabela; Pintado, Manuela (2014). Wild mushroom extracts potentiate the action of standard antibiotics against multi-resistant bactéria. Journal of Applied Microbiology. 1364-5072. 116, p. 32-38por
dc.identifier.doi10.1111/jam.12348
dc.identifier.issn1364-5072
dc.identifier.urihttp://hdl.handle.net/10198/12073
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectAntibioticspor
dc.subjectMultiresistant bacteriapor
dc.subjectSynergismpor
dc.subjectWild mushroom extractspor
dc.titleWild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteriapor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.citation.endPage38por
oaire.citation.startPage32por
oaire.citation.titleJournal of Applied Microbiologypor
oaire.citation.volume116por
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlves
person.familyNameFerreira
person.familyNamePereira
person.familyNameMartins
person.givenNameMaria José
person.givenNameIsabel C.F.R.
person.givenNameLiliana
person.givenNameAnabela
person.identifier144781
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-idEF14-9663-7872
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-0211-6205
person.identifier.orcid0000-0001-6218-4413
person.identifier.ridM-6624-2016
person.identifier.ridE-8500-2013
person.identifier.ridG-5488-2013
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id7203013518
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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