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Bioactivity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins

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dc.contributor.authorDias, Maria Inês
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorSoković, Marina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-03-28T10:40:58Z
dc.date.available2014-03-28T10:40:58Z
dc.date.issued2013
dc.description.abstractLaurus nobilis L. (Laureaceae), commonly known as laurel, is a native plant from the Mediterranean region. Most widely used as culinary spice, it is also consumed as infusion to treat some gastrointestinal problems (Dall’Acqua et al., 2009) and has been reported as a rich source of bioactive compounds namely, essential oils and phenolic compounds (Dadalioğlu et al., 2004; Dias et al., 2013). In the present work, methanolic and aqueous extracts of wild and cultivated L. nobilis were studied for their in vitro antitumor (against five different human tumor cell lines) and antimicrobial (antibacterial and antifungal) activities. Furthermore, a two-dimensional principal component analysis (PCA) was used to understand how each extract act differentially towards specific bacterial and fungal species, and also selected human tumor cell lines. Both assayed factors, origin (wild or cultivated) and extract type (methanolic or aqueous) act in a differentiated manner; i.e., the same evaluated parameter gave sometimes statistically significant differences regarding laurel origin, but no effect at all from extract type, or vice versa. Nevertheless, the extract type induced the most marked changes in bioactivity of laurel samples. From the PCA biplot, it became clear that wild samples were more effective to inhibit tumor cell lines growth, especially HeLa, MCF7, NCI-H460 and HCT15. It was also observed that methanolic extracts tended to have higher antimicrobial activity, except for Aspergillus niger, Aspergillus. fumigatus and Penicillium verrucosum. The differences in bioactivity might be related to the higher phenolic compounds content (flavonols, flavones and even, total phenolic compounds) presented by methanolic extracts,. The most interesting finding in this work was the bioactive specificity of each laurel extract, considering its wild or cultivated origin. Moreover, from the PCA biplot obtained is possible to choose the combination extract type/origin with potentially highest effect against determined bacteria, fungi or tumor cell line, depending on the objective of the study.por
dc.description.sponsorshipFCT for financial support, CIMO (strategic project PEst-OE/AGR/UI0690/2011), REQIMTE (PEst-C/EQB/LA0006/2011), M.I. Dias (SFRH/BD/84485/2012), R.C. Calhelha (SFRH/BPD/68344/2010) and J.C.M. Barreira (BPD/72802/2010)por
dc.identifier.citationDias, Maria Inês; Calhelha, Ricardo C.; Barreira, João C.M.; Queiroz, Maria João R.P.; Oliveira, M. Beatriz P.P.; Soković, Marina; Ferreira, Isabel C.F.R. (2013). Bioactivity of methanolic and aqueous extracts of Laurus nobilis L. from different origins. In Encontro de Jovens Investigadores do Instituto Politécnico de Bragançapor
dc.identifier.urihttp://hdl.handle.net/10198/9403
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - LA 6 - 2011-2012
dc.relationIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.subjectAntimicrobialpor
dc.subjectAntitumoralspor
dc.subjectLaurus nobilis L.por
dc.subjectPCApor
dc.subjectPhenolic compoundspor
dc.titleBioactivity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Originspor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - LA 6 - 2011-2012
oaire.awardTitleIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEQB%2FLA0006%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F84485%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.conferencePlaceBragança,Portugalpor
oaire.citation.titleEncontro de Jovens Investigadores do Instituto Politécnico de Bragançapor
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameDias
person.familyNameCalhelha
person.familyNameBarreira
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameJoão C.M.
person.givenNameIsabel C.F.R.
person.identifier144781
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person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-2172-2014
person.identifier.ridD-8269-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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