Antioxidant capacities of flavones and benefits in oxidative-stress related diseases

Catarino, Marcelo D.; Alves-Silva, Jorge M.; Pereira, Olívia R.; Cardoso, Susana M.

Publication

Antioxidant capacities of flavones and benefits in oxidative-stress related diseases

2015Journal article

dc.contributor.author	Catarino, Marcelo D.
dc.contributor.author	Alves-Silva, Jorge M.
dc.contributor.author	Pereira, Olívia R.
dc.contributor.author	Cardoso, Susana M.
dc.date.accessioned	2015-04-27T14:31:08Z
dc.date.available	2015-04-27T14:31:08Z
dc.date.issued	2015
dc.description.abstract	Flavonoids, a group of secondary metabolites widely distributed in the plant kingdom, have been acknowledged for their interesting medicinal properties. Among them, natural flavones, as well as some of their synthetic derivatives, have been shown to exhibit several biological activities, including antioxidant, anti-inflammatory, antitumor, anti-allergic, neuroprotective, cardioprotective and antimicrobial. The antioxidant properties of flavones allow them to demonstrate potential application as preventive and attenuating agents in oxidative stress, i.e., a biological condition that is closely associated to aging process and several diseases. Some flavones interfere in distinct oxidative-stress related events by directly reducing the levels of intracellular free radicals (hydroxyl, superoxide and nitric oxide) and/or of reactive species (e.g. hydrogen peroxide, peroxynitrite and hypochlorous acid) thus preventing their amplification and the consequent damage of other biomolecules such as lipids, proteins and DNA. Flavones can also hinder the activity of central free radical-producing enzymes, such as xanthine oxidase and nicotinamide adenine dinucleotide phosphate oxidase (NADPH-oxidase) or inducible nitric oxide synthase (iNOS) and can even modulate the intracellular levels of pro-oxidant and/or antioxidant enzymes. The evaluation of flavones antioxidant ability has been extensively determined in chemical or biological in vitro models, but in vivo therapy with individual flavones or with flavones-enriched extracts has also been reported. The present manuscript revises relevant studies focusing the preventive effects of flavones on stress-related diseases, namely the neurological and cardiovascular diseases, and diabetes and its associated complications.	por
dc.identifier.citation	Catarino, Marcelo D.; Alves-Silva, Jorge M.; Pereira, Olívia R.; Cardoso, Susana M. (2015). Antioxidant capacities of flavones and benefits in oxidative-stress related diseases. In Current Topics in Medicinal Chemistry. ISSN 1568-0266. 15:2, p. 105-119	por
dc.identifier.doi	10.2174/1568026615666141209144506
dc.identifier.issn	1568-0266
dc.identifier.uri	http://hdl.handle.net/10198/11796
dc.language.iso	eng	por
dc.peerreviewed	yes	por
dc.publisher	Bentham Science Publishers	por
dc.subject	Antioxidant activity	por
dc.subject	Coronary heart diseases	por
dc.subject	Diabetes	por
dc.subject	Flavones	por
dc.subject	Neurodegenerative disorders	por
dc.subject	Oxidative stress related	por
dc.subject	Structure-activity relationship	por
dc.title	Antioxidant capacities of flavones and benefits in oxidative-stress related diseases	por
dc.type	journal article
dspace.entity.type	Publication
oaire.awardURI	info:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0681%2F2014/PT
oaire.citation.endPage	119	por
oaire.citation.startPage	105	por
oaire.citation.title	Current Topics in Medicinal Chemistry	por
oaire.citation.volume	15	por
oaire.fundingStream	5876
person.familyName	Pereira
person.givenName	Olívia R.
person.identifier	145216
person.identifier.ciencia-id	B312-AF21-D2FA
person.identifier.orcid	0000-0002-6275-3134
person.identifier.rid	H-1049-2014
person.identifier.scopus-author-id	52264387000
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	por
rcaap.type	article	por
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