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The use of response surface methodology to optimize assisted extraction of bioactive compounds from Cucurbita maxima fruit by-products

2023Journal article Open access
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dc.contributor.authorBen Mansour, Rim
dc.contributor.authorFalleh, Hanen
dc.contributor.authorHammami, Majdi
dc.contributor.authorBarros, Lillian
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorTarchoun, Neji
dc.contributor.authorKsouri, Riadh
dc.date.accessioned2022-05-17T11:11:22Z
dc.date.available2022-05-17T11:11:22Z
dc.date.issued2023
dc.description.abstractThis work aimed to optimize the extraction conditions of bioactive compounds obtained from three squash by-products (e.g., peel, endocarp, and seeds) using the response surface methodology (RSM). The selected independent variables were ethanol concentration, extraction time, and extraction temperature. Squash by-products' bioactive molecules were extracted according to the matrix proposed by the experimental plan. Significant variability in total phenolic compound content (TPC) and antioxidant activity, depending on the extraction time, the solvent concentration, and the extraction temperature, was recorded for the tested by-products. The experimental results adequately fitted with second-order polynomial models and showed significant linear, quadratic, and interaction effects of the independent variables. Data analysis suggested that the optimal extraction conditions were 12.2% ethanol for 11.2 min at 55 & DEG;C for peels; 28.5% ethanol for 10.5 min at 37 & DEG;C for endocarp; and 20% ethanol for 10.5 min at 60 & DEG;C for seeds. The results obtained showed that the experimental and predicted values of TPC and antioxidant activities as an indicator of a successful extraction fit with each other, thus indicating the optimal extraction conditions. Under these conditions, the obtained extracts exhibited high, although variable, TPC with epicatechin and epigallocatechin as major compounds, as well significant antimicrobial potency, which reached 100% and 80% inhibition of the tested bacteria and fungi.pt_PT
dc.description.sponsorshipThis study was supported by the Tunisian Ministry of Higher Education, Scientific Research, Information, and Communication Technologies and the Foundation for Science and Technology and was funded under the scope of the Project PulpIng (PRIMA/0007/2019)-H2020-PRIMA 2019—Section 2—Multi-topic 2019; the Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021); by FCT for the contract of L. Barros (CEEC Institutional); and by the General Secretariat for Research and Technology of the Ministry of Development and Investments under the PRIMA Program. PRIMA is an Art.185 initiative supported and co-funded under Horizon 2020, the European Union’s Program for Research and Plants 2022, 11, 800 16 of 18 Innovation (Prima2019-08).
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBen Mansour, Rim; Falleh, Hanen; Hammami, Majdi; Barros, Lillian; Petropoulos, Spyridon Α.; Tarchoun, Neji; Ksouri, Riadh (2023). The use of response surface methodology to optimize assisted extraction of bioactive compounds from Cucurbita maxima fruit by-products. Processes. eISSN 2227-9717. 11:6, p. 1-22pt_PT
dc.identifier.doi10.3390/pr11061726
dc.identifier.eissn2227-9717
dc.identifier.urihttp://hdl.handle.net/10198/25466
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCucurbita maxima
dc.subjectBy-products
dc.subjectResponse surface methodology
dc.subjectAntioxidant activity
dc.subjectTotal phenolic compound content
dc.subjectSquash
dc.titleThe use of response surface methodology to optimize assisted extraction of bioactive compounds from Cucurbita maxima fruit by-productspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleProcesses
person.familyNameBarros
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01

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