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Improvement of local ozone phytotoxicity modelling for autochthonous grape cultivars

2023Journal article Open access
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dc.contributor.authorBlanco-Ward, Daniel
dc.contributor.authorRibeiro, A.C.
dc.contributor.authorFeliciano, Manuel
dc.contributor.authorBarreales, David
dc.contributor.authorPaoletti, Elena
dc.contributor.authorMiranda, Ana Isabel
dc.date.accessioned2023-01-17T11:47:32Z
dc.date.available2023-01-17T11:47:32Z
dc.date.issued2023
dc.description.abstractCervical cancer prevention is based on primary prevention with vaccines against Human Papillomavirus (HPV) and secondary prevention by screening with High-Risk-HPV (Hr-HPV) detection. Since 2017, cervical cancer screening in women aged 25-60 years has been performed in Portugal using Hr-HPV detection, followed by cytology in Hr-HPV-positive cases. Herein we report the prevalence of Hr-HPV genotypes and cytological abnormalities among 462401 women (mean age: 43.73 +/- 10.79; median age: 45; range: 24-66 years) that participated in the Regional Cervical Cancer Screening Program of the Northern Region of Portugal, performed between August 2016 and December 2021. Overall, we describe a prevalence rate of 12.50% for Hr-HPV varying from 20.76% at age 25% to 8.32% at age 64. The five most common Hr-HPV genotypes identified were HPV-68 (16.09%), HPV-31 (15.30%), HPV-51 (12.96%), HPV-16 (11.06%), and HPV-39 (11.01%). The prevalence of Hr-HPV included in the nonavalent vaccine (HPV-9valent) was 55.00% ranging from 47.78% to 59.18% across different age groups. Considering positive Hr-HPV cases, 65.68% had a Negative for Intraepithelial Lesion or Malignancy (NILM) cytology, 20.83% atypical squamous cells of undetermined significance (ASC-US), 8.85% Low-Grade Squamous Intraepithelial Lesion (LSIL), 1.65% High-Grade Squamous Intraepithelial Lesion (HSIL), 2.85% ASC-H, 0.09% Atypical Glandular Cells, 0.02% Adenocarcinomas, and 0.02% Squamous Cell Carcinoma (SCC). Our analysis revealed that HPV-9val genotypes were responsible for 52.13% NILM, 59.21% ASC-US, 55.06% LSIL, 90.14% HSIL, 83.50% ASC-H, and 100.00% SCC. Furthermore, multiple Hr-HPV infections (risk ratio [RR] = 1.46; 95% confidence interval [CI] 1.34-1.58), HPV-16/18 (RR = 5.16; 95% CI 4.75-5.93), or HPV-9val genotypes (RR = 5.23; 95% CI 4.68-5.85) were associated with a significant risk of developing > HSIL (p < 0.001). To date, this is the largest study on Hr-HPV genotyping in cervical cancer screening that includes data from a complete cycle of the screening program. Our findings suggest a high prevalence of HPV-9valent genotypes and a significant association with an increased risk of developing > HSIL. This constitutes important data for health authorities, which may help define the future of vaccination and cervical cancer screening strategies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBlanco-Ward, Daniel; Ribeiro, A.C.; Feliciano, Manuel; Barreales, David; Paoletti, Elena; Miranda, Ana Isabel. (2023). Improvement of local ozone phytotoxicity modelling for autochthonous grape cultivars. Atmospheric Environment. eISSN 1873-2844. 295, p. 1-15pt_PT
dc.identifier.doi10.1016/j.atmosenv.2022.119538
dc.identifier.eissn1873-2844
dc.identifier.issn1352-2310
dc.identifier.urihttp://hdl.handle.net/10198/26561
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOzone phytotoxicitypt_PT
dc.subjectCritical dosept_PT
dc.subjectModellingpt_PT
dc.subjectField campaignpt_PT
dc.subjectGrapevinept_PT
dc.subjectLeaf water potential
dc.subjectMountainous terrain
dc.subjectMediterranean conditions
dc.titleImprovement of local ozone phytotoxicity modelling for autochthonous grape cultivarspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAtmospheric Environmentpt_PT
person.familyNameRibeiro
person.familyNameFeliciano
person.familyNameBarreales
person.givenNameAntónio C.
person.givenNameManuel
person.givenNameDavid
person.identifier.ciencia-id9D19-E833-BE97
person.identifier.ciencia-id2D11-7230-702B
person.identifier.ciencia-idFA16-8DE7-6968
person.identifier.orcid0000-0002-8280-9027
person.identifier.orcid0000-0002-3147-4511
person.identifier.orcid0000-0002-8425-0167
person.identifier.scopus-author-id6603358480
person.identifier.scopus-author-id57202136257
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb7ecf809-561e-40ce-86b0-603a60433710
relation.isAuthorOfPublicationccb9c69d-2820-493b-ab44-77b0538814fa
relation.isAuthorOfPublication44d42f8e-7185-4c33-9551-66928841ce3e
relation.isAuthorOfPublication.latestForDiscoveryccb9c69d-2820-493b-ab44-77b0538814fa

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