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Microencapsulation of plant extracts rich in apigenin to be used as chemopreventive agents in functional foods

dc.contributor.authorOliveira, Franciely dos Santos de
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFernandes, Isabel P.
dc.contributor.authorDemczuk Junior, Bogdan
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarreiro, M.F.
dc.date.accessioned2015-11-05T15:42:13Z
dc.date.available2015-11-05T15:42:13Z
dc.date.issued2015
dc.description.abstractAngiogenesis is the process by which new blood vessels are formed from pre-existing vasculature, being a key process that leads to tumor development. Excessive angiogenesis occurs when diseased cells produce abnormally large amounts of angiogenesis factors (e.g. vascular endothelial growth factor (VEGF)) [1]. Some studies recognize phenolic compounds as chemopreventive agents; flavonoids seem to suppress the growth of tumor cells modifying the cell cycle and inducing apoptosis in several tumor cell lines [2]. Among them, apigenin derivatives have been recognized as having antiangiogenic effects on tumor cells being this related to a decrease in VEGF expression or to a VEGFR inhibition [3]. According to Ferreira et al. previous research, Arenaria montana L. is rich in apigenin derivatives [4]. Therefore, this plant source is ideal to prepare apigenin rich extracts to be used as chemoprevent i ve agents in functional foods. However, bioactive compounds are generally recognized as presenting problems of instability, which can weaken their bioavailability and potential benefits. Therefore, the use of microencapsulation is studied here as a way to confer protection and increasing the efficacy of functional foods incorporating these extracts [5]. In this work, a hydroethanolic extract prepared from A. montana was evaluated for its in vitro antiangiogenic effects, being further microencapsulated to be used as chemopreventive agent in functional yogurts.pt_PT
dc.identifier.citationOliveira, F.S.; Calhelha, Ricardo C.; Fernandes, I.P.; Junior, B.D.; Ferreira, Isabel C.F.R.; Barreiro, M.F. (2015). Microencapsulation of plant extracts rich in apigenin to be used as chemopreventive agents in functional foods. In 6th Workshop on Green Chemistry and Nanotechnologies in Polymer Chemistry. Bragança. ISBN 978-972-745-188-3pt_PT
dc.identifier.isbn978-972-745-188-3
dc.identifier.urihttp://hdl.handle.net/10198/12291
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationNORTE-07-0124-FEDER-000014pt_PT
dc.relationPRODER Project 46577- PlantLactpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleMicroencapsulation of plant extracts rich in apigenin to be used as chemopreventive agents in functional foodspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FEQU%2F50020%2F2013/PT
oaire.citation.title6th Workshop on Green Chemistry and Nanotechnologies in Polymer Chemistrypt_PT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameCalhelha
person.familyNameFernandes
person.familyNameFerreira
person.familyNameBarreiro
person.givenNameRicardo C.
person.givenNameIsabel P.
person.givenNameIsabel C.F.R.
person.givenNameFilomena
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id4D1C-441F-C7F0
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id3418-47D5-5746
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-0069-4503
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridJ-2172-2014
person.identifier.ridL-1552-2016
person.identifier.ridE-8500-2013
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id26323585300
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id57188719717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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