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Antimicrobial, cytotoxic and antioxidante activity of Amaranthaceae plants: a renewable source of nutrients and phenolic compounds.

2021Conference object Open access
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dc.contributor.authorNúñez Estévez, Bernabé
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorCarpena Rodríguez, María
dc.contributor.authorOtero, Paz
dc.contributor.authorBarral Martínez, Marta
dc.contributor.authorPires, Tânia C.S.
dc.contributor.authorMandim, Filipa
dc.contributor.authorPinela, José
dc.contributor.authorGarcía-Pérez, Pascual
dc.contributor.authorSimal-Gandara, Jesus
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorPrieto Lage, Miguel A.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2022-01-21T12:15:07Z
dc.date.available2022-01-21T12:15:07Z
dc.date.issued2021
dc.description.abstractSince the beginning of the 21st century, food products have been subjected to numerous tests to check their quality and presence of harmful agents. Nowadays, consumers awareness about food quality has increased dramatically, paying much attention to the identification of artificial additives, which are normally included as preservative ingredients, among others. This change is also represented in the food industry, where the use of natural food texturizers and preservatives has been replacing some commonly used artificial additives, thus motivating the search for new bioactive compounds from natural sources. Among such bioactive compounds, plant secondary metabolites, in special phenolic compounds, have been largely reported for their health-enhancing properties and preservative effect. In this study, a phytochemical and nutritional characterization of three species from the Amaranthaceae family (Alternanthera sessilis (L.) R., Dicliptera chinensis (L.) Juss. and Dysphania ambrosioides (L.) Mosyakin & Clemants) was performed. The antioxidant and antimicrobial activities and cytotoxicity to tumour and non-tumour cell lines were also evaluated using different methodologies. The results showed a high content of flavonoids in the ethanolic extract of the three species, ranging 11.4 – 15.1 mg/g extract, with apigenin, luteolin and isorhamnetin derivatives being the most abundant compounds. On the other hand, the results from nutritional analysis showed a high protein content in the species studied (13.9- 16.9 ± 0.1 g/100 g of dry weight, dw), together with the presence of organic acids, such as oxalic and succinic acids. Concerning the reported bioactivities of the plant extracts, the results for cytotoxic activity showed GI50 values ranging from 263 ± 12 μg/mL to 188 ± 14 μg/mL towards different tumor cell lines (colon carcinoma, Caco-2; breast adenocarcinoma, MCF-7; and non-small cell lung, NCI-H460) and no cytotoxic activity in the control cell line (Vero). Moreover, with respect to antimicrobial activity, the A. sessilis extract showed minimal inhibitory concentrations (MIC) of 5 mg/mL against Morganella morganii, as well as the D. abrosioides extract against methicillin-resistant Staphylococcus aureus (MRSA). For the antioxidant activity determined by the oxidative haemolysis assay (OxHLIA), the D. abrosioides extract showed an IC50 of 66 ± 10 μg/mL. Overall, these results suggest that ethanolic extracts from the characterized Amaranthaceae species, exhibiting a high bioactive potential, can be considered as promising natural ingredients or additives in the food industry.pt_PT
dc.description.sponsorshipThe research leading to these results was funded by Xunta de Galicia supporting the Axudas Conecta Peme, the IN852A 2018/58 NeuroFood Project and the program EXCELENCIA-ED431F 2020/12; to Ibero-American Program on Science and Technology (CYTED—AQUA-CIBUS, P317RT0003) and to the Bio Based Industries Joint Undertaking (JU) under grant agreement No 888003 UP4HEALTH Project (H2020-BBI-JTI-2019); by MICINN supporting the Ramón y Cajal grant for M.A. Prieto (RYC-2017-22891); by EcoChestnut Project (Erasmus+ KA202) that supports the work of B. Nuñez-Estevez. The JU receives support from the European Union’s Horizon 2020 research and innovation program and the Bio Based Industries Consortium. The project SYSTEMIC Knowledge hub on Nutrition and Food Security, has received funding from national research funding parties in Belgium (FWO), France (INRA), Germany (BLE), Italy (MIPAAF), Latvia (IZM), Norway (RCN), Portugal (FCT), and Spain (AEI) in a joint action of JPI HDHL, JPI-OCEANS and FACCE-JPI launched in 2019 under the ERA-NET ERA-HDHL (n° 696295). To the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to the CIMO (UIDB/00690/2020). L. Barros and R. Calhelha thank the national funding by FCT, P.I., through the institutional scientific employment program-contract for their contracts, and J. Pinela (CEECIND/01011/2018) through the individual scientific employment program-contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNuñez-Estevez, B.; Finimundy, Tiane C.; Carpena, Maria; Otero, Paz; Barral-Marinez, M.; Pires, Tânia C.S.P.; Mandim, Filipa; Pinela, José; Garcia-Perez, P.; Simal-Gandara, Jesus; Ferreira, Isabel C.F.R.; Prieto Lage, Miguel A.; Barros, Lillian (2021). Antimicrobial, cytotoxic and antioxidante activity of Amaranthaceae plants: a renewable source of nutrients and phenolic compounds. In XV Encontro de Química dos Alimentos. Funchal. ISBN 978-989-8805-68-3pt_PT
dc.identifier.isbn978-989-8805-68-3
dc.identifier.urihttp://hdl.handle.net/10198/24822
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAmaranthaceae plantspt_PT
dc.subjectAntioxidant activitypt_PT
dc.titleAntimicrobial, cytotoxic and antioxidante activity of Amaranthaceae plants: a renewable source of nutrients and phenolic compounds.pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceMadeira, Portugalpt_PT
oaire.citation.titleXV Encontro Química dos Alimentospt_PT
person.familyNameNúñez Estévez
person.familyNameFinimundy
person.familyNamePires
person.familyNameMandim
person.familyNamePinela
person.familyNameFerreira
person.familyNamePrieto Lage
person.familyNameBarros
person.givenNameBernabé
person.givenNameTiane C.
person.givenNameTânia C.S.P.
person.givenNameFilipa
person.givenNameJosé
person.givenNameIsabel C.F.R.
person.givenNameMiguel A.
person.givenNameLillian
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person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-3513-0054
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridQ-2842-2018
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rcaap.rightsopenAccesspt_PT
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