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Optimisation of a tannin-rich extract using response surface methodology

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dc.contributor.authorSilva, Ana Rita
dc.contributor.authorPinela, José
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorGarcía, Pablo A.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2022-01-31T11:10:11Z
dc.date.available2022-01-31T11:10:11Z
dc.date.issued2021
dc.description.abstractTannins are a class of phenolic compounds commonly found in plants and studied for their in vitro bioactive and enzyme inhibitory properties [1,2]. Cytinus hypocistis (L.) L. is a wild edible parasitic plant on various Cistaceae family members, which biological properties (antioxidant, anti-tyrosinase, anti-inflammatory, and antimicrobial) have been correlated with its high tannin content. Thus, studying the extraction optimisation of tannins from C. hypocistis will give comprehensive clues for the enhanced recovery of these high added- value bioactive compounds and their potential cosmeceutical applications [2]. The present work used Response Surface Methodology (RSM) to optimise tannins extraction using both a conventional (Heat-Assisted Extraction – HAE) and a sustainable extraction method (Ultrasound- Assisted Extraction – UAE). Two three-factor Rotatable Central Compound Designs (RCCDs) were applied to evaluate the linear, quadratic, and interactive effects of the independent variables X1 [t: time (min)], X2 [T: temperature (°C) or P: ultrasonic power (W)], and X3 [S: solvent ratio (% of ethanol/water, v/v)]. The software Design-Expert v11 was used to generate the 20 experimental runs by entering the factor ranges in alphas (α = 1.68). Each variable to be optimised was coded at five levels: -1.68, -1, 0, +1, and +1.68. The constructed polynomial models were statistically validated based on high R2 values and nonsignificant lack-of-fit and used to predict the optimal extraction conditions. The obtained results from both extraction systems revealed higher ethanol percentages as the critical factor for increasing the final response (mg total tannins/g extract). The optimum global processing conditions predicted by the models were 95 min, 46 °C, and 74% ethanol for HAE, and 18 min, 327 W, and 69% ethanol for UAE. Following these conditions, 234 mg and 175 mg of total tannins per g of extract were recovered using HAE and UAE, correspondingly. Even though the HAE technique presented a higher final response, the UAE offers sustainable and economic advantages in time and energy consumption. These results confirm the scale-up potential of C. hypocistis as a valuable source of a tannin-rich extract.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). A. R. Silva is grateful to FCT for her Doctoral Grant (SFRH/BD/145834/2019) and J. Pinela and L. Barros for the contracts through the individual (CEECIND/01011/2018) and institutional scientific employment program-contract, respectively. The authors are also thankful to the FEDER-Interreg España-Portugal programme for financial support through the project TRANSCoLAB 0612_TRANS_CO_LAB_2_P and to ERDF through the Regional Operational Program North 2020, within the scope of the Project GreenHealth - Norte-01-0145-FEDER-000042.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, Ana Rita; Pinela, José; Ferreira, Isabel C.F.R.; García, Pablo; Barros, Lillian (2021). Optimisation of a tannin-rich extract using response surface methodology. In 1st Natural products application: health, cosmetic and food: book of abstracts. Bragança: Instituto Politécnico. ISBN 978-972-745-286-6pt_PT
dc.identifier.isbn978-972-745-286-6
dc.identifier.urihttp://hdl.handle.net/10198/24960
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCEECIND/01011/2018pt_PT
dc.relationMountain Research Center
dc.relationCytinus hypocistis L. L.: a case study for the development of an innovative, safe, and effective anti-photoaging cosmeceutical formulation
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCytinus hypocistis (L.)pt_PT
dc.titleOptimisation of a tannin-rich extract using response surface methodologypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumberUIDB/00690/2020
oaire.awardNumberSFRH/BD/145834/2019
oaire.awardTitleMountain Research Center
oaire.awardTitleCytinus hypocistis L. L.: a case study for the development of an innovative, safe, and effective anti-photoaging cosmeceutical formulation
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F145834%2F2019/PT
oaire.citation.conferencePlaceonline editionpt_PT
oaire.citation.titleNatural products application: Health, Cosmetic, and Foodpt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameSilva
person.familyNamePinela
person.familyNameFerreira
person.familyNameBarros
person.givenNameAna Rita
person.givenNameJosé
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifierABD-5857-2020
person.identifier144781
person.identifier469085
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person.identifier.orcid0000-0001-5819-9065
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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