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Melipona scutellaris geopropolis: chemical composition and bioactivity

2023Journal article Open access
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dc.contributor.authorCoutinho, Sónia
dc.contributor.authorMatos, Vanessa
dc.contributor.authorSeixas, Natália
dc.contributor.authorRodrigues, Hellen
dc.contributor.authorPaula, Vanessa B.
dc.contributor.authorFreitas, Lais
dc.contributor.authorDias, Teresa
dc.contributor.authorSantos, Francisco de A.R.
dc.contributor.authorDias, L.G.
dc.contributor.authorEstevinho, Leticia M.
dc.date.accessioned2014-10-23T14:02:06Z
dc.date.available2014-10-23T14:02:06Z
dc.date.issued2023
dc.description.abstractGeopropolis has been used in traditional medicine for centuries. In this study, the botanical origin, physicochemical profile, and biological activities of geopropolis from Melipona scutellaris harvested during rainy and dry seasons were investigated. Palynological analysis identified over 50 pollen types, with Schinus terebinthifolius and Cecropia being the predominant types. The analytical results were in line with those reported in the literature. Rainy-season geopropolis exhibited higher total phenol and flavonoid content (determined using High Performance Liquid Chromatography-25.13% and 3.92%, respectively) compared to the dry season (19.30% and 2.09%); the major peaks (naringin, gallic acid, and catechin) were similar among samples. Antioxidant capacity was assessed via DPPH, reducing power, and beta-carotene/linoleic acid discoloration assays. Rainy-season samples displayed superior antioxidant activity across methods. Antimicrobial effects were determined using microdilution, while the impact on the cholinesterase enzyme was quantified using 5-thio-2-nitrobenzoic acid accumulation. Anti-inflammatory and antimutagenic activities were assessed through hyaluronidase enzyme inhibition and by utilizing Saccharomyces cerevisiae ATCC-20113 cells. Both samples exhibited anti-inflammatory and antimutagenic properties. Moreover, a significant inhibition of acetylcholinesterase was observed, with IC50 values of 0.35 mu g/mL during the rainy season and 0.28 mu g/mL during the dry season. Additionally, the geopropolis displayed antimicrobial activity, particularly against Staphylococcus aureus. These findings suggest the therapeutic potential of M. scutellaris geopropolis in the context of inflammatory, oxidative, and infectious diseases.por
dc.identifier.citationCoutinho, Sónia; Matos, Vanessa; Seixas, Natália; Rodrigues, Hellen; Paula, Vanessa B.; Freitas, Lais; Dias, Teresa; Santos, Francisco de A.R.; Dias, L.G.; Estevinho, Leticia M. (2023). Melipona scutellaris geopropolis: chemical composition and bioactivity. Microorganisms. eISSN 2076-2607. 11:11, p. 1-18por
dc.identifier.doi10.3390/microorganisms11112779
dc.identifier.eissn2076-2607
dc.identifier.urihttp://hdl.handle.net/10198/10988
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPIpor
dc.subjectBeehive productspor
dc.subjectBeehive productspor
dc.subjectGeopropolispor
dc.subjectNatural productspor
dc.titleMelipona scutellaris geopropolis: chemical composition and bioactivitypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMicroorganismspor
person.affiliation.nameInstituto Politécnico de Bragança
person.familyNameSeixas
person.familyNamePaula
person.familyNameFreitas
person.familyNameDias
person.familyNameDias
person.familyNameEstevinho
person.givenNameNatália
person.givenNameVanessa B.
person.givenNameLais
person.givenNameTeresa
person.givenNameLuís G.
person.givenNameLetícia M.
person.identifier142703
person.identifier.ciencia-idC816-E8C4-7D3F
person.identifier.ciencia-id5F16-A866-562D
person.identifier.ciencia-idB31A-CF76-55C0
person.identifier.ciencia-id2F11-9092-FAAF
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0001-7281-8598
person.identifier.orcid0000-0002-9419-9561
person.identifier.orcid0000-0002-1210-4259
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id56830642600
person.identifier.scopus-author-id23569169900
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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