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Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization

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dc.contributor.authorGonçalves, Miguel A.D.
dc.contributor.authorPinto, Virgínia
dc.contributor.authorCosta, Rita Alexandra Santos da
dc.contributor.authorDias, Rolando
dc.contributor.authorHernándes-Ortiz, Júlio
dc.contributor.authorCosta, Mário Rui
dc.date.accessioned2014-06-02T11:18:28Z
dc.date.available2014-06-02T11:18:28Z
dc.date.issued2013
dc.description.abstractTemperature and pH stimuli-responsive hydrogel particles were synthesized using inverse-suspension polymerization in batch stirred reactor. Different water soluble co-monomers were present in the initial mixture (e.g. N-isopropylacrylamide and acrylic acid) as well as crosslinkers with different functionalities. Different operating conditions such as polymerization temperature, monomers dilution, neutralization and the initial ratios of co-monomers and monomers/crosslinker were also tried. Hydrogel particles were produced considering classical free-radical polymerization (FRP) and also RAFT polymerization. Commercially available RAFT agents 4-cyano-4-phenylcarbonothioylthio-pentanoic acid (CPA), 2-(dodecylthiocarbonothioylthio)-2-methylpropionic acid (DDMAT) and cyanomethyl dodecyl trithiocarbonate (CDT) were alternatively used. Sampling at different polymerization times allowed the study of the kinetics of polymerization through the analysis by SEC of the soluble phase. A tetra-detector array with simultaneous detection of refractive index, light scattering, intrinsic viscosity and ultra-violet signals was used in these studies. Usefulness of in-line FTIR-ATR monitoring to study the building process of such networks was also assessed. The performance of hydrogel beads was studied through drug delivery tests triggered by changes in the environmental temperature and pH. This research aims to contribute for the elucidation of the connection between the synthesis conditions, molecular architecture and properties/performance of such advanced materials.por
dc.description.sponsorshipFCT and FSE (Programa Operacional Potencial Humano/POPH) through the PhD scholarship SFRH/BD/76587/2011. FCT through researcher scholarship in the framework of the project PTDC/EQU-EQU/098150/2008 (Ministry of Science and Technology of Portugal/Program COMPETE - QCA III/ European Community/FEDER). Marie Curie Initial Training Network “Nanopoly” (Project: ITN-GA-2009-238700) program SAESCTN - PIIC&DT/1/2011, Programa Operacional Regional do Norte (ON.2), contract NORTE-07-0124-FEDER-000014 (RL2_P3 Polymer Reaction Engineering).por
dc.description.sponsorshipFCT through researcher scholarship in the framework of the project PTDC/EQU-EQU/098150/2008 (Ministry of Science and Technology of Portugal/Program COMPETE - QCA III/ European Community/FEDER)
dc.identifier.citationGonçalves, Miguel; Pinto, Virgínia; Costa, Rita; Dias, Rolando; Hernándes-Ortiz, Julio; Costa, Mário Rui (2013). Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization. In Polymer Reaction Engineering – 11th International Workshop e Macromolecular Symposia - Special Issue: Polymer Reaction Engineering. Hamburg. WILEY-VCH. p. 41-54.por
dc.identifier.doi10.1002/masy.201300045
dc.identifier.urihttp://hdl.handle.net/10198/9614
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWILEY-VCHpor
dc.relationMolecular Engineering, Synthesis and Testing of Water Compatible Smart Polymers
dc.subjectCrosslinkingpor
dc.subjectHydrogelspor
dc.subjectRAFTpor
dc.subjectStimuli-responsive polymerspor
dc.titleStimuli-responsive hydrogels synthesis using free radical and RAFT polymerizationpor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMolecular Engineering, Synthesis and Testing of Water Compatible Smart Polymers
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEQU-EQU%2F098150%2F2008/PT
oaire.citation.conferencePlaceHamburgpor
oaire.citation.endPage54por
oaire.citation.startPage41por
oaire.citation.titleMacromolecular Symposia - Special Issue: Polymer Reaction Engineeringpor
oaire.citation.volume333por
oaire.fundingStream5876-PPCDTI
person.familyNameDias
person.givenNameRolando
person.identifier.ciencia-id8417-4D84-973B
person.identifier.orcid0000-0001-7369-382X
person.identifier.ridM-8552-2013
person.identifier.scopus-author-id7102885104
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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