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Preparation of nano-hydroxyapatite/chitosan aqueous dispersions: from lab scale to continuous production using an innovative static mixer

2018Journal article Open access
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dc.contributor.authorRuphuy, Gabriela
dc.contributor.authorWeide, T.
dc.contributor.authorLopes, José Carlos B.
dc.contributor.authorDias, Madalena M.
dc.contributor.authorBarreiro, M.F.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2019-02-04T14:35:45Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2019-02-04T14:35:45Z
dc.date.issued2018
dc.description.abstractChitosan is widely used in the preparation of organic-inorganic composite materials, such as n-HAp/CS composites, which findapplication for bone regeneration. The methods for their preparation are various, and usually based on the preparation of intermediate n-HAp/CS dispersions, which can greatly influence the final properties of the resulting composites since it is expected that homogenous and stable dispersions lead to composite materials with improved final properties. This work hypothesizes that, additionally to process parameters such as pH, n-HAp/CS weight ratio, mixing conditions and the presence of salts, chitosan itself has a high impact on dispersions stability. Thus, the importance of properly control the preparation of the n-HAp/CS intermediate dispersions is highlighted by doing a systematic study where relevant processing parameters were studied at lab scale using ultrasonication, alone or in the presence of chitosan, namely on particle size and zeta potential. Furthermore, and based on the best laboratorial conditions, the production of n-HAp/CS nanocomposite dispersions in continuous mode was attempted through NETmix® technology,an innovative static mixer and reactor developed at the Associate Laboratory LSRE-LCM of the Faculty of Engineering of the University of Porto(FEUP).en_EN
dc.description.sponsorshipFinancial support for this work was provided in part by project Project POCI-01-0145-FEDER-006984 – Associate Laboratory LSRELCM funded by FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT - Fundação para a Ciência e a Tecnologia, and by “AIProcMat@N2020 - Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020”, with reference NORTE-01-0145-FEDER-000006, supported by NORTE 2020 under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). FCT and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013). G. Ruphuy thanks Universidad de Costa Rica (UCR) and Ministerio de Ciencia, Tecnología y Telecomunicaciones de Costa Rica (MICITT) for her scholarship. Authors thank Fluidinova S.A. for providing the HAp samples.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationRuphuy, G.; Weide, T.; Lopes, J.; Dias, M.M.; Barreiro, M.F. (2018). Preparation of nano-hydroxyapatite/chitosan aqueous dispersions: From lab scale to continuous production using an innovative static mixer. Carbohydrate Polymers. ISSN 0144-8617. 202, p. 20-28en_EN
dc.identifier.doi10.1016/j.carbpol.2018.08.123en_EN
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10198/18628
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationPT2020
dc.relationPOCI-01-0145-FEDER-006984
dc.subjectChitosanen_EN
dc.subjectDispersion stabilityen_EN
dc.subjectNano-compositesen_EN
dc.subjectNano-hydroxyapatiteen_EN
dc.subjectNETmix technologyen_EN
dc.titlePreparation of nano-hydroxyapatite/chitosan aqueous dispersions: from lab scale to continuous production using an innovative static mixeren_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.fundingStream5876
person.familyNameBarreiro
person.givenNameFilomena
person.identifier.ciencia-id3418-47D5-5746
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id57188719717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication0391987c-ba90-488b-839a-153447ce1f0f
relation.isAuthorOfPublication.latestForDiscovery0391987c-ba90-488b-839a-153447ce1f0f
relation.isProjectOfPublicationcfb6e380-87c4-4772-8c2c-76799a53d6df
relation.isProjectOfPublication.latestForDiscoverycfb6e380-87c4-4772-8c2c-76799a53d6df

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