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Xanthones constitute an important class of heterocyclic compounds that commonly occur in
nature. The inclusion of aryl groups has only been reported for a few synthetic derivatives,
being the 2,3-diaryl moiety recently introduced by our group.~
The pharmacological properties of both natural and synthetic xanthones have attracted great
attention namely as antioxidant, anti-allergic, anti-inflammatory, antimalarial and antitumour
protectors. The antioxidant activity deserves special mention, considering the potent scavenging
activity for reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal
chelating activity already reported for some compounds bearing the xanthone scaffold.
Thus, the main goal of this work was to evaluate the putative scavenging effect on NO, ONOO- and O2 - of the new synthetic 2,3-diarylxanthones (Figure 1), using in vitro non-cellular systems
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Santos, Clementina M.M.; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda (2010). ROS and RNS Scavenging Activity by 2,3-Diarylxanthones. In International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species. Salamanca