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Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

2015Journal article Open access
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dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorReis, Filipa S.
dc.contributor.authorStojković, Dejan
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorVasconcelos, M. Helena
dc.contributor.authorSoković, Marina
dc.date.accessioned2015-11-24T15:36:28Z
dc.date.available2015-11-24T15:36:28Z
dc.date.issued2015
dc.description.abstractGanoderma genus comprises one of the most commonly studied species worldwide, Ganoderma lucidum. However, other Ganoderma species have been also reported as important sources of bioactive compounds. Polysaccharides are important contributors to the medicinal properties reported for Ganoderma species, as demonstrated by the numerous publications, including reviews, on this matter. Yet, what are the chemical features of Ganoderma polysaccharides that have bioactivity? In the present manuscript, the chemical features of Ganoderma polysaccharides with reported antioxidant, antitumor and antimicrobial activities (the most studied worldwide) are analyzed in detail. The composition of sugars (homo- versus hetero-glucans and other polysaccharides), type of glycosidic linkages, branching patterns, and linkage to proteins are discussed. Methods for extraction, isolation and identification are evaluated and, finally, the bioactivity of polysaccharidic extracts and purified compounds are discussed. The integration of data allows deduction of structure-activity relationships and gives clues to the chemical aspects involved in Ganoderma bioactivity.pt_PT
dc.identifier10.1016/j.phytochem.2014.10.011
dc.identifier.citationFerreira, Isabel C.F.R.; Heleno, Sandrina A.; Reis, Filipa S.; Stojković, Dejan; Queiroz, Maria João R.P.; Vasconcelos, M. Helena; Soković, Marina (2015) – Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. Phytochemistry. ISSN 0031-9422. 114, p. 38-55pt_PT
dc.identifier.doi10.1016/j.phytochem.2014.10.011pt_PT
dc.identifier.issn0031-9422
dc.identifier.urihttp://hdl.handle.net/10198/12412
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGanodermapt_PT
dc.subjectPolysaccharidespt_PT
dc.subjectChemical featurespt_PT
dc.subjectBioactivitypt_PT
dc.subjectStructure-activitypt_PT
dc.titleChemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activitiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage55pt_PT
oaire.citation.startPage38pt_PT
oaire.citation.titlePhytochemistrypt_PT
oaire.citation.volume114pt_PT
person.familyNameFerreira
person.familyNameHeleno
person.familyNameReis
person.givenNameIsabel C.F.R.
person.givenNameSandrina A.
person.givenNameFilipa S.
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0002-9159-0530
person.identifier.ridE-8500-2013
person.identifier.ridL-5951-2014
person.identifier.ridI-2093-2013
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id36982144400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublicatione89b5bf5-d315-49b6-871e-fa8eb6030676
relation.isAuthorOfPublicationb8d384ae-2134-4735-93a6-0d2febbf9220
relation.isAuthorOfPublication.latestForDiscoveryb8d384ae-2134-4735-93a6-0d2febbf9220

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