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Development of stimuli-responsive graphene-based yolk-shell magnetic nanoparticles for controlled release of anticancer drugs

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dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorBaldi, Giovanni
dc.contributor.authorDoumett, Saer
dc.contributor.authorBañobre-López, Manuel
dc.contributor.authorGallo, Juan
dc.contributor.authorDražić, Goran
dc.contributor.authorLima, Rui A.
dc.contributor.authorSilva, Adrián
dc.contributor.authorGomes, Helder
dc.date.accessioned2017-01-12T14:54:40Z
dc.date.available2017-01-12T14:54:40Z
dc.date.issued2016
dc.description.abstractMagnetic drug delivery systems have attracted much attention in the last decades due to the possibility to improve the therapeutic efficacy of anticancer drugs, by enabling instable and poorly soluble drug agents to reach tumour cells after being guided by low magnetic fields and monitored by magnetic resonance imaging (MRI) [1]. Hence, a lower amount of anticancer drug is needed and the typical side effects of chemotherapy are minimized [2]. Commonly, these nanoparticles are designed with a magnetic core coated with a metal or a non-metal structure, such as gold or silica. However, these approaches present some drawbacks, such as low drug loading capacity and lack of stimuli-responsive release. Alternatively, carbon-coated magnetic nanoparticles offer higher chemical and thermal stability, larger surface area, biocompatibility and easier functionalization due to the high capacity of adsorption. Moreover, these materials have shown great ability to be used as pH stimuli-responsive controlled release platforms, due to the disruption of supramolecular  interaction at acidic pH [3]. In this context, graphene-coated yolk-shell magnetic nanoparticles – hybrid materials comprising a superparamagnetic core coated by a graphene-based shell that covers a hollow region (i.e., Fe3O4@void@C), – were developed as super-drug nanocarriers systems, exhibiting high loading contents of the anticancer drug Doxorubicin due to the large cavity volume between the shell and the magnetic core, and a stimuliresponsive controlled release in response to acidic environments (pH 5), such as those found in tumour tissues. These results shed light on the development of new hybrid nanomaterials with high potential to be applied in biomedical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodrigues, Raquel; Baldi, Giovanni; Doumett, Saer; Bañobre-López, Manuel; Gallo, Juan; Dražić, Goran; Lima, R. : Silva, Adrián; Gomes, Helder (2016). Development of stimuli-responsive graphene-based yolk-shell magnetic nanoparticles for controlled release of anticancer drugs. In XXII Encontro Luso-Galego de Química. Bragançapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/13744
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnticancer drugspt_PT
dc.titleDevelopment of stimuli-responsive graphene-based yolk-shell magnetic nanoparticles for controlled release of anticancer drugspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F97658%2F2013/PT
oaire.citation.conferencePlaceBragançapt_PT
oaire.citation.endPage61pt_PT
oaire.citation.startPage61pt_PT
oaire.citation.titleXXII Encontro Luso-Galego de Químicapt_PT
person.familyNameLima
person.familyNameGomes
person.givenNameRui A.
person.givenNameHelder
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.ciencia-id6218-1E19-13EE
person.identifier.orcid0000-0003-3428-637X
person.identifier.orcid0000-0001-6898-2408
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication7b50c499-8095-4f4f-8b1b-fa7388e4ff62
relation.isAuthorOfPublication0eb96337-224a-4339-9918-334436fbbb99
relation.isAuthorOfPublication.latestForDiscovery7b50c499-8095-4f4f-8b1b-fa7388e4ff62
relation.isProjectOfPublication95f49ee8-5b1f-45de-b818-d9334a4d8d0e
relation.isProjectOfPublication.latestForDiscovery95f49ee8-5b1f-45de-b818-d9334a4d8d0e

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