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Antifungal activity and detailed chemical characterization of Cistus ladanifer phenolic extracts

2013Journal article Open access
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dc.contributor.authorBarros, Lillian
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorAlves, Carlos Tiago
dc.contributor.authorSilva, Sónia
dc.contributor.authorHenriques, Mariana
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2012-08-23T09:19:14Z
dc.date.available2012-08-23T09:19:14Z
dc.date.issued2013
dc.description.abstractThe life-threatening mycoses caused by opportunistic fungal pathogens (mainly species from the genus Candida) associated with nosocomial infections, are one of the major health problems in our days. Therefore, it is crucial to identify new compounds, especially natural ones, that are active against the most broaden spectrum of Candida species. Herein, a screening of the antifungal potential of a phenolic extract of Cistus ladanifer from Northeastern Portugal, against Candida species was performed. Furthermore, the extract was characterized by HPLC-DAD-ESI/MS. Phenolic acids and derivatives (3.96 mg/g extract), ellagic acid derivatives (30.34 mg/g extract), and flavonoids (4.15 mg/g extract), such as catechins, flavonols and flavones, were found in the sample. The most abundant group was ellagic acid derivatives in which punicalagin gallate, a derivative of punicalagin attached to gallic acid, was found in highest amount (15.99 ± 0.02 mg/g extract). These compounds (i.e., ellagitannins) could be related to the strong inhibition of C. albicans, C. glabrata and C. parapsilosis growth (MIC < 0.05 mg/ml). Moreover, the best antifungal activity was against C. glabrata, where the studied extract was able to cause at least 3 Log of reduction at concentrations below 0.05 mg/mL and a total growth inhibition at concentrations above 0.625 mg/mL.por
dc.identifier.citationBarros, Lillian; Dueñas, Montserrat; Alves, Carlos Tiago; Silva, Sónia; Henriques, Mariana; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2012). Antifungal activity and detailed chemical characterization of Cistus ladanifer phenolic extracts. Industrial Crops and Products. ISSN 0926-6690. 41, p. 41-45por
dc.identifier.doi10.1016/j.indcrop.2012.03.038
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/7379
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationSFRH/BPD/4609/2008
dc.subjectCistus ladaniferpor
dc.subjectPhenolic compoundspor
dc.subjectHPLC-DAD-ESI/MSpor
dc.subjectCandida speciespor
dc.subjectAntifungal activitypor
dc.titleAntifungal activity and detailed chemical characterization of Cistus ladanifer phenolic extractspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage45por
oaire.citation.startPage41por
oaire.citation.titleIndustrial Crops and Productspor
oaire.citation.volume41por
person.familyNameBarros
person.familyNameFerreira
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8

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