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Ganoderma Lucidum effects in an animal model of obesity

2021Conference object Open access
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dc.contributor.authorCastro-Ribeiro, Catarina
dc.contributor.authorSilva-Reis, Rita
dc.contributor.authorMendes-Gonçalves, Mariana
dc.contributor.authorFerreira, Tiago
dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorBarros, Lillian
dc.contributor.authorMartins, Tânia
dc.contributor.authorFaustino-Rocha, Ana
dc.contributor.authorPires, Maria João
dc.contributor.authorPinto, M.L.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorVenâncio, Carlos
dc.contributor.authorRosa, Eduardo
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2022-01-21T11:38:24Z
dc.date.available2022-01-21T11:38:24Z
dc.date.issued2021
dc.description.abstractObesity is a pandemic disease, and its evolution can be influenced by regular consumption of natural bioactive compounds. Mushrooms, such as Ganoderma lucidum (GL), include a wide variety of biomolecules with potential anti-obesity effects. This work aimed to study the influence of GL in an animal model of obesity. Forty-eight male mice (C57BL/6J) were divided into 5 groups: Group (G)-1-Western Control Diet; G-2-Western Diet 0.2% Cholesterol (WDC); G-3-WDC+0.7g/kg of GL; G-4-WDC+1.4g/ kg of GL; G-5 WDC+2.8g/kg of GL. Water and food consumption were recorded weekly. Animals were weighed individually, and their temperature was measured on the back and abdomen (thermographic camera FLIRE6390). Thirteen weeks later, animals were sacrificed, and organs collected. A liver portion was used for histopathology analysis (ethical approval nº 8776). Chemical characterization of the GL extract was profiled by HPLC-DAD-ESI/MS. Ganoderic acid H and p-hydroxybenzoic acid were the main triterpenic and phenolic acids in the extract, respectively. Food and water consumption were no different among groups. All animals showed weight gain (11-16%): animals without GL supplementation showed the highest weight gain (G2 and G1, respectively); the groups with GL showed the lowest weight gain, which decreased as the mushroom concentration increased. Basal and final body temperatures remained constant. Liver weight was different among groups (p<0.05). Microvesicular (39/47; 83%) and macrovesicular fatty changes (steatosis) were the most frequent morphological changes in the liver. Hyperlipidemic diets consumption promoted weight gain and obesity. The higher weight gain in the groups not supplemented with GL suggested its anti-obesity properties. In this study, animals developed steatosis, which was not modified by GL supplementation. However, it should be noticed that the changes in lipid metabolism are reversible, and the differences observed in the liver relative weights, lower in the groups supplemented with GL, suggested an ongoing process of restoring to normal hepatocyte’s phenotype.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCastro-Ribeiro, Catarina; Silva-Reis, Rita; Mendes-Gonçalves, Mariana; Ferreira, Tiago; Taofiq, Oludemi; Barros, Lillian; Martins, T.; Faustino-Rocha, A.I.; Pires, M.J.; Pinto, M.L.; Ferreira, Isabel C.F.R.; Venâncio, C.; Rosa, E.; Oliveira, P.A. (2021). Ganoderma Lucidum effects in an animal model of obesity. In Webinar on Animal and Veterinary Science. Malvernpt_PT
dc.identifier.urihttp://hdl.handle.net/10198/24818
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPhronesispt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectObesitypt_PT
dc.titleGanoderma Lucidum effects in an animal model of obesitypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceMalvernpt_PT
oaire.citation.endPage16pt_PT
oaire.citation.startPage16pt_PT
oaire.citation.titleWebinar on Animal and Veterinary Sciencept_PT
person.familyNameBarros
person.familyNameFerreira
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8

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