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Extracts from berries of Portuguese Vitis vinifera L. varieties Vinhão and Loureiro exhibit powerful antioxidant, antihaemolytic, and cytotoxic activities

2025Artigo científico Acesso aberto
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorNipo, Maria
dc.contributor.authorSimões, Luara
dc.contributor.authorNoronha, Henrique
dc.contributor.authorBarros, Lillian
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorPereira, Carla
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorParpot, Pier
dc.contributor.authorŠevčovičová, Andrea
dc.contributor.authorOliveira, Rui
dc.date.accessioned2026-04-13T11:09:08Z
dc.date.available2026-04-13T11:09:08Z
dc.date.issued2025
dc.description.abstractGrapes (Vitis vinifera L.) are widely consumed fruits known for their diverse bioactive compounds. Vinhão and Loureiro are the major red and white grape varieties, respectively, of the largest Portuguese wine region: Vinho Verde. Large amounts of residues are produced in wine making that potentially are rich in bioactive compounds, so this study aimed at valorizing the residues from these grape varieties for further applications. The grape extracts were obtained from the seeds and from the pulp and skin together for characterization. The phenolic composition differed across these parts, with the seeds being particularly rich in polyphenols and flavonoids. Both varieties exhibited high antioxidant activity; seed extracts stood out, showing the strongest radical scavenging ability (IC50 = 0.22 +/- 0.08 for 2,2-diphenyl-1-picrylhydrazyl and 0.004 +/- 0.001 mg mL-1 for thiobarbituric acid reactive substances assays). The Loureiro seed extract showed higher antihaemolytic properties (IC50 = 4.81 +/- 0.22 mu g mL-1) by protecting erythrocyte membranes from oxidative damage. The seed extracts displayed cytotoxic potential on tested tumor cells, particularly with the Loureiro variety. Overall, the results suggest that both varieties have high antioxidant properties, with the seed extracts showing the most promising bioactivities. Although further characterization is required in terms of bioactivity in in vivo experimental models, these findings contribute to the potential utilization of grape extracts and their waste products, providing new applications for Portuguese grape varieties in various applications, such as pharmaceuticals, cosmetics, and nutraceuticals.eng
dc.description.sponsorshipThis work was supported by the “Contrato-Programa” UIDB/04050/2020 funded by national funds through the Foundation for Science and Technology (FCT) I.P (https://doi.org/10.54499/UIDB/04050/2020) and by AgrifoodXXI (NORTE-01-0145-FEDER-000041). This work was supported by national funds through the Foundation for Science and Technology (FCT) UID/QUI/0686/2020 (Centre of Chemistry UMinho) and UIDB/04469/2020 (Centre of Biological Engineering UMinho). This work was financially supported by national funds through FCT/MCTES (PIDDAC): CIMO, UIDB/00690/2020 (DOI: https://doi.org/10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: https://doi.org/10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: https://doi.org/10.54499/LA/P/0007/2020); and national funding by FCT, P.I., through the institutional and individual scientific employment program contract for L. Barros (DOI: https://doi.org/10.54499/CEECINST/00107/2021/CP2793/CT0002), C. Pereira, and R. Calhelha (DOI: https://doi.org/10.54499/CEECINST/00016/2018/CP1505/CT0009).
dc.identifier.citationNipo, Maria; Simões, Luara; Noronha, Henrique; Barros, Lillian; Finimundy, Tiane C.; Pereira, Carla; Calhelha, Ricardo; Parpot, Pier; Ševčovičová, Andrea; Oliveira, Rui (2025) Extracts from berries of Portuguese Vitis vinifera L. varieties Vinhão and Loureiro exhibit powerful antioxidant, antihaemolytic, and cytotoxic activities. Journal of Food Measurement and Characterization. ISSN 2193-4126. 20:1, p. 426–441
dc.identifier.doi10.1007/s11694-025-03727-3
dc.identifier.issn2193-4126
dc.identifier.issn2193-4134
dc.identifier.urihttp://hdl.handle.net/10198/36526
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relationCentre of molecular and environmental biology
dc.relationCentre of Biological Engineering of the University of Minho
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationMountain Research Center
dc.relationUIDB/04050/2020
dc.relation.ispartofJournal of Food Measurement and Characterization
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectBioactivities
dc.subjectAntioxidant activity
dc.subjectSeed extracts
dc.subjectVinhão grape variety
dc.subjectLoureiro grape variety
dc.titleExtracts from berries of Portuguese Vitis vinifera L. varieties Vinhão and Loureiro exhibit powerful antioxidant, antihaemolytic, and cytotoxic activitieseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDP/04050/2020
oaire.awardNumberUIDB/04469/2020
oaire.awardNumberLA/P/0007/2020
oaire.awardNumberUIDB/00690/2020
oaire.awardTitleCentre of molecular and environmental biology
oaire.awardTitleCentre of Biological Engineering of the University of Minho
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04050%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.endPage441
oaire.citation.issue1
oaire.citation.startPage426
oaire.citation.titleJournal of Food Measurement and Characterization
oaire.citation.volume20
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBarros
person.familyNameFinimundy
person.familyNamePereira
person.familyNameCalhelha
person.givenNameLillian
person.givenNameTiane C.
person.givenNameCarla
person.givenNameRicardo C.
person.identifier469085
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id2F18-67B1-776A
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-3516-0795
person.identifier.orcid0000-0001-9010-8725
person.identifier.orcid0000-0002-6801-4578
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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