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Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil

2018Journal article Open access
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dc.contributor.authorZan, Renato André
dc.contributor.authorFernandes, Ângela
dc.contributor.authorJedoz, Stephanie
dc.contributor.authorOludemi, Taofiq
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorPires, Tânia C.S.
dc.contributor.authorAlves, Maria José
dc.contributor.authorMartins, Roberto Carlos Campos
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2019-02-04T17:01:59Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2019-02-04T17:01:59Z
dc.date.issued2018
dc.description.abstractLeaf fractions of Garcinia brasiliensis were evaluated concerning their antioxidant, antimicrobial, anti inflammatory and cytotoxic properties, and the most active fraction was then fully characterized regarding its phenolic composition using HPLC-DAD-ESI/MSn. The ethyl acetate fraction from partitioning of the methanolic leaf extract revealed a strong antioxidant activity that was comparable to Trolox, the positive control. This fraction was also able to show a significant antimicrobial activity against Gram-positive and Gram-negative bacteria and the fungus Candida albicans. However, the dichloromethane fraction was found to present the highest anti-inflammatory (83 ± 9 µg mL−1) and cytotoxic activities, thus presenting slight toxicity using a non-tumor cell line. Regarding the phenolic profile, the ethyl acetate fraction presented twelve flavonoids, with morelloflavone-7’’-O-glucoside (52.1 ± 0.4 mg g−1) and gardinia biflavonoid 2a glucoside (27.5 ± 0.2 mg g−1) being the major compounds identified. These results indicate that leaves of G. brasiliensis might be a potential source of natural biomolecules for pharmaceutical and medicinal applications.en_EN
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013) and L. Barros’s contract; to the FEDER-Interreg España- Portugal programme for financial support through the project 0377_Iberphenol_6_E.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationZan, Renato André; Fernandes, Ângela; Jedoz, Stephanie; Oludemi, Taofiq; Calhelha, Ricardo C.; Pires, Tânia C.S.P.; Alves, Maria José; Martins, Roberto Carlos Campos; Barros, Lillian; Ferreira, Isabel C.F.R. (2018) - Bioactive properties and phytochemical assessment of Bacupari-anão (: Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil. Food and Function. ISSN 2042-6496. 9, p. 5621-5628en_EN
dc.identifier.doi10.1039/c8fo01474den_EN
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/18669
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.titleBioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazilen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.fundingStream5876
person.familyNameFernandes
person.familyNameOludemi
person.familyNameCalhelha
person.familyNamePires
person.familyNameAlves
person.familyNameBarros
person.familyNameFerreira
person.givenNameÂngela
person.givenNameTaofiq
person.givenNameRicardo C.
person.givenNameTânia C.S.P.
person.givenNameMaria José
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier2118829
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2015-0434-AE7C
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person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridQ-2842-2018
person.identifier.ridM-6624-2016
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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