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Status and challenges of plant-anticancer compounds in cancer treatment

2021Journal article Open access
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dc.contributor.authorGarcia-Oliveira, Paula
dc.contributor.authorOtero, Paz
dc.contributor.authorPereira, Antia Gonzalez
dc.contributor.authorChamorro Rivo, Franklin Noel
dc.contributor.authorCarpena Rodríguez, María
dc.contributor.authorEchave Álvarez, Javier
dc.contributor.authorFraga-Corral, Maria
dc.contributor.authorSimal-Gandara, Jesus
dc.contributor.authorPrieto Lage, Miguel A.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-12-02T16:31:43Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-12-02T16:31:43Z
dc.date.issued2021
dc.description.abstractNowadays, cancer is one of the deadliest diseases in the world, which has been estimated to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve monochemotherapy or a combination of radiotherapy and mono-chemotherapy. However, the negative side effects of these approaches have been extensively reported and have prompted the search of new therapeutic drugs. In this context, scientific community started to look for innovative sources of anticancer compounds in natural sources, including traditional plants. Currently, numerous studies have evaluated the anticancer properties of natural compounds derived from plants, both in vitro and in vivo. In pre-clinical stages, some promising compounds could be mentioned, such as the sulforaphane or different phenolic compounds. On the other hand, some phytochemicals obtained positive results in clinical stages and were further approved for cancer treatment, such as vinca alkaloids or the paclitaxel. Nevertheless, these compounds are not exempt of limitations, such as low solubility, restricted effect on their own, negative side-effects, etc. This review aims to compile the information about the current phytochemicals used for cancer treatment and also promising candidates, main action mechanisms and also reported limitations. In this sense, some strategies to face the limitations have been considered, such as nano-based formulations to improve solubility or chemical modification to reduce toxicity. In conclusion, although more research is still necessary to develop more efficient and safe phytochemical drugs, more of these compounds might be used in future cancer therapies.en_EN
dc.description.sponsorshipThe research leading to these results was supported by: MICINN supporting the Ramón&Cajal grant for M.A. Prieto (RYC-2017-22891), the project UP4HEALTH for supporting the researcher P. Otero, the Xunta de Galicia and University of Vigo supporting the post-doctoral grant for M. Fraga-Corral (ED481B-2019/096) and the pre-doctoral grants for P. García-Oliveira (ED481A-2019/295) and A.G. Pereira (ED481A-2019/0228).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGarcia-Oliveira, Paula; Otero, Paz; Pereira, Antia Gonzalez; Chamorro, Franklin; Carpena, Maria; Echave, Javier; Fraga-Corral, Maria; Simal-Gandara, Jesus; Prieto, Miguel Angel (2021). Status and challenges of plant-anticancer compounds in cancer treatment. Pharmaceuticals. ISSN 1424-8247. 14:2, p. 1-28en_EN
dc.identifier.doi10.3390/ph14020157en_EN
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10198/24432
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
dc.subjectAnticanceren_EN
dc.subjectChallengesen_EN
dc.subjectClinical/pre-clinical studiesen_EN
dc.subjectNatural compoundsen_EN
dc.subjectTraditional plantsen_EN
dc.titleStatus and challenges of plant-anticancer compounds in cancer treatmenten_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/888003/EU
oaire.fundingStreamH2020
person.familyNameGarcía-Oliveira
person.familyNameFraga-Corral
person.familyNamePrieto Lage
person.givenNamePaula
person.givenNameMaria
person.givenNameMiguel A.
person.identifier1054547
person.identifier107688
person.identifier.ciencia-id781F-C144-9DBD
person.identifier.ciencia-id1616-98AD-4546
person.identifier.ciencia-id221E-1E00-AB74
person.identifier.orcid0000-0003-4058-3709
person.identifier.orcid0000-0002-5663-9239
person.identifier.orcid0000-0002-3513-0054
person.identifier.ridG-7335-2017
person.identifier.ridG-4516-2011
person.identifier.scopus-author-id56346469200
person.identifier.scopus-author-id35937495700
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication2317d016-9037-42de-81b9-fe1cd505b8c5
relation.isAuthorOfPublication446f0a90-be7c-4111-9949-42475fda0e6a
relation.isAuthorOfPublication13260615-fd28-4b8b-9dd4-8a8466007579
relation.isAuthorOfPublication.latestForDiscovery446f0a90-be7c-4111-9949-42475fda0e6a
relation.isProjectOfPublication9980c0d6-0317-49a0-a44d-b8aedf2294a5
relation.isProjectOfPublication.latestForDiscovery9980c0d6-0317-49a0-a44d-b8aedf2294a5

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