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Salvia elegans, Salvia greggii and Salvia officinalis Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes

2018Journal article Open access
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dc.contributor.authorPereira, Olívia R.
dc.contributor.authorCatarino, Marcelo D.
dc.contributor.authorAfonso, Andrea Luísa Fernandes
dc.contributor.authorSilva, Artur
dc.contributor.authorCardoso, Susana M.
dc.date.accessioned2019-01-08T15:19:11Z
dc.date.available2019-01-08T15:19:11Z
dc.date.issued2018
dc.description.abstractSalvia elegans Vahl., Salvia greggii A. Gray, and Salvia officinalis L. decoctions were investigated for their health-benefit properties, in particular with respect to antioxidant activity and inhibitory ability towards key enzymes with impact in diabetes and obesity (α-glucosidase, α-amylase and pancreatic lipase). Additionally, the phenolic profiles of the three decoctions were determined and correlated with the beneficial properties. The S. elegans decoction was the most promising in regard to the antioxidant effects, namely in the scavenging capacity of the free radicals DPPH•, NO• and O2•–, and the ability to reduce Fe3+, as well as the most effective inhibitor of α-glucosidase (EC50 = 36.0 ± 2.7 μg/mL vs. EC50 = 345.3 ± 6.4 μg/mL and 71.2 ± 5.0 μg/mL for S. greggii and S. officinalis, respectively). This superior activity of the S. elegans decoction over those of S. greggii and S. officinalis was, overall, highly correlated with its richness in caffeic acid and derivatives. In turn, the S. officinalis decoction exhibited good inhibitory capacity against xanthine oxidase activity, a fact that could be associated with its high content of flavones, in particular the glycosidic forms of apigenin, scutellarein and luteolin.pt_PT
dc.description.sponsorshipThe Science and Technology Foundation/Ministry of Education and Science (FCT/MEC) funded the Organic Chemistry, Natural Products and Food Stuffs Research Unit (QOPNA) research unit (FCT UID/QUI/00062/2013) through national funds and, where applicable, was co-financed by the European Regional Development Fund (FEDER), within the Portugal 2020. Project AgroForWealth (CENTRO-01-0145-FEDER-000001), funded by Centro2020, through FEDER and PT2020, financed the research contract of Susana M. Cardoso. The Science and Technology Foundation financed Marcelo D. Catarino (fellowship PD/BD/114577/2016).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira, Olívia R.; Catarino, Marcelo D.; Afonso, Andrea F.; Silva, Artur; Cardoso, Susana M. (2018). Salvia elegans, Salvia greggii and Salvia officinalis Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes. Molecules. ISSN 1420-3049. 23:12, p. 1-17pt_PT
dc.identifier.doi10.3390/molecules23123169pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/18339
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationExtraction, strctural characterization and biological activity of phlorotannins from Brown Algae
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSagept_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectAntioxidantpt_PT
dc.subjectα-glucosidasept_PT
dc.subjectPancreatic lipasept_PT
dc.subjectα-amylasept_PT
dc.subjectLC-MS analysispt_PT
dc.titleSalvia elegans, Salvia greggii and Salvia officinalis Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExtraction, strctural characterization and biological activity of phlorotannins from Brown Algae
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00062%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/PD%2FBD%2F114577%2F2016/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.endPage17pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume23pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
person.familyNamePereira
person.familyNameAfonso
person.givenNameOlívia R.
person.givenNameAndrea Luísa Fernandes
person.identifier145216
person.identifier.ciencia-idB312-AF21-D2FA
person.identifier.ciencia-id9C1D-41E7-9BBF
person.identifier.orcid0000-0002-6275-3134
person.identifier.orcid0000-0002-8858-1617
person.identifier.ridH-1049-2014
person.identifier.scopus-author-id52264387000
person.identifier.scopus-author-id36766901000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationaf7d647c-f5a6-48f7-afcf-6307c3677b1d
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