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Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides.

2017Journal article Open access
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dc.contributor.authorSantos, Cintia Miranda
dc.contributor.authorCampos, Jaqueline Ferreira
dc.contributor.authorSantos, Jaqueline Freitas dos
dc.contributor.authorBalestieri, José Benedito Perrella
dc.contributor.authorSilva, Denise Brentan
dc.contributor.authorSouza, Kely de Picoli
dc.contributor.authorCarollo, Carlos Alexandre
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorSantos, Edson Lucas dos
dc.date.accessioned2020-06-05T09:23:09Z
dc.date.available2020-06-05T09:23:09Z
dc.date.issued2017
dc.description.abstractStingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections.pt_PT
dc.description.sponsorshipThis work was supported by grants from Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Universidade Federal da Grande Dourados (UFGD), and PRODER (24.073 – Â, Portugal).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, Cintia Miranda; Campos, Jaqueline Ferreira; Santos, Jaqueline Freitas dos; Balestieri, José Benedito Perrella; Silva, Denise Brentan; Souza, Kely Picoli; Carollo, Carlos Alexandre; Estevinho, Leticia M.; Santos, Edson Lucas dos (2017). Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. Oxidative Medicine and Cellular Longevity. ISSN 1942-0900. p. 1-13pt_PT
dc.identifier.doi10.1155/2017/8320804pt_PT
dc.identifier.eissn1942-0994
dc.identifier.issn1942-0900
dc.identifier.urihttp://hdl.handle.net/10198/22025
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawipt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectBrazilian propolispt_PT
dc.subjectFree-radicalspt_PT
dc.subjectAntibacterialpt_PT
dc.titleChemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides.pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13pt_PT
oaire.citation.issue8320804pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleOxidative Medicine and Cellular Longevitypt_PT
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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