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Antioxidant, photoprotective and inhibitory activity of tyrosinase in extracts of Dalbergia ecastaphyllum

dc.contributor.authorMorais, Daniel Vieira
dc.contributor.authorCosta, Maria Angélica Carvalho
dc.contributor.authorBárbara, Marivalda
dc.contributor.authorSilva, Fabiane de Lima
dc.contributor.authorMoreira, Manuela M.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorDias, L.G.
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorCarvalho, Carlos Alfredo Lopes de
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2019-02-04T17:03:08Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2019-02-04T17:03:08Z
dc.date.issued2018
dc.description.abstractDalbergia ecastaphyllum is a native Brazil plant with importance for beekeeping, and widely used in folk medicine. For the first time, the extracts of this plant were assessed for the presence of hydrophilic and lipophilic antioxidants, as well as inhibition of tyrosinase, free radicals scavenging and sunscreen protection. The antioxidant activity was evaluated by free radical scavenging (DPPH) andβ-carotene bleaching assay. The tyrosinase inhibitory activity was evaluated and calculated the EC50. The photoprotective activity was measured using different concentrations of D. ecastaphyllum extracts. The Sun Protection Factor (SPF) of the samples was higher than 6, and the sample from Ilhe ´us showed the most pronounced photoprotective effect. Sample from Canavieiras presented the highest antioxidant activity by free radical scavenging DPPH andβ-carotene bleaching method, with 92.41% and 48.34%, respectively. All samples inhibited the tyrosinase, especially the sample from Prado that was most effective (124.62μg.mL-1). Significant negative correlation was found between flavonoid contents and inhibition of tyrosinase. The overall results provide relevant information about the Dalbergia ecastaphyllum species, indicating as potential material to cosmetic and pharmaceutical industry.en_EN
dc.description.sponsorshipWe thank MSc Vandira Pereira da Mata for the support during the sample collection
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationMorais, Daniel Vieira; Costa, Maria Angélica; Bárbara, Marivalda ; Silva, Fabiane; Moreira, Manuela M.; Delerue-Mato, C.; Dias, L.G.; Estevinho, Leticia M.; Carvalho, Carlos Alfredo (2018). Antioxidant, photoprotective and inhibitory activity of tyrosinase in extracts of Dalbergia ecastaphyllum. PLoS ONE. ISSN 1932-6203. 13en_EN
dc.identifier.doi10.1371/journal.pone.0207510en_EN
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10198/18679
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.titleAntioxidant, photoprotective and inhibitory activity of tyrosinase in extracts of Dalbergia ecastaphyllumen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameDias
person.familyNameEstevinho
person.givenNameLuís G.
person.givenNameLetícia M.
person.identifier.ciencia-id2F11-9092-FAAF
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-1210-4259
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id23569169900
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublicationeac8c166-4056-4ed0-8d8d-7ecb2c4481a5
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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