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Aminosquaraines as potential photodynamic agents: Synthesis and evaluation of in vitro cytotoxicity

2017Journal article Open access
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dc.contributor.authorMagalhães, F.
dc.contributor.authorGraça, Vânia C.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSantos, Paulo F.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-30T15:00:00Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-30T15:00:00Z
dc.date.issued2017
dc.description.abstract© 2017 Elsevier Ltd The synthesis of several aminosquaraine cationic dyes displaying strong absorption within the so-called phototherapeutic window (650–850 nm) is described. Their cytotoxicity, under dark and illuminated conditions, was tested against several human tumor cell lines (breast, lung, cervical and hepatocellular carcinomas) and non-tumor porcine liver primary cells. All compounds showed to inhibit the growth of the tumor cells upon irradiation more than in the absence of light, in more or less extension, clearly exhibiting photodynamic activity. The photosensitizing ability against some cell lines, together with the low toxicity for the non-tumor primary PLP2 cells displayed by some of the compounds synthetized, turns them into potential candidates as photosensitizers for PDT.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER for CIMO (UID/AGR/00690/2013) and CQ-VR (UID/QUI/00616/2013) financial support.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMagalhães, F.; Graça, Vânia C.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Santos, Paulo F. (2017). Aminosquaraines as potential photodynamic agents: Synthesis and evaluation of in vitro cytotoxicity. Bioorganic and Medicinal Chemistry Letters. ISSN 0960-894X. 27, p. 4467-4470en_EN
dc.identifier.doi10.1016/j.bmcl.2017.08.004pt_PT
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/10198/15263
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.subjectCanceren_EN
dc.subjectPhotodynamic therapyen_EN
dc.subjectPhotosensitizeren_EN
dc.subjectSquaraine dyesen_EN
dc.titleAminosquaraines as potential photodynamic agents: Synthesis and evaluation of in vitro cytotoxicityen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00616%2F2013/PT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
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