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Borututu, artichoke and milk thistle: chemical profiles, antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity

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dc.contributor.authorPereira, Carla
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-10-29T11:06:55Z
dc.date.available2015-10-29T11:06:55Z
dc.date.issued2014
dc.description.abstractArtichoke, borututu and milk thistle are medicinal plants widely consumed as infusions or included in dietary supplements for the treatment prevention of liver diseases. In the present work, their nutritional value was assessed and analytical tools (gas and liquid chromatography coupled to different detectors) were used to distinguish the chemical profiles namely in hydrophilic (sugars and organic acids) and lipophilic (fatty acids and tocopherols) compounds [1]. Furthermore, antioxidant properties (radicals scavenging activity, reducing power, and lipid peroxidation inhibition), anti-hepatocellular carcinoma activity (HepG2 tumor cell line) and toxicity (non-tumor liver cells primary culture) of their infusions and dietary supplements (pills and syrups) were evaluated and compared [2,3]. Borututu gave the highest energetic value with the highest content of carbohydrates and fat, sucrose and total sugars, shikimic and citric acids, a-, 13-. 5- and total tocopherols. Artichoke had the highest ash and protein contents, oxalic acid, SFA (mainly palmitic Acid), and y-tocopherol, as also the best n6/n3 ratio. Milk thistle showed the highest levels of fructose and glucose, quinic acid and total organic acids, PUFA, mainly linoleic acid, and the best PUFNSFA ratio. All the samples revealed antioxidant properties with EC50 values lower than the daily recommended dose, but infusions showed higher activity than dietary supplements, with the exception of milk thistle syrup, that gave similar EC50 values to the borututu infusion. Among all the samples, the pills revealed the lowest antioxidant activity. The syrup of milk thistle and the infusions of borututu and artichoke revealed anti-hepatocellular carcinoma activity, but the latest also showed toxicity for normal cells at a higher concentration. None of the pills showed cytotoxicity. Thereby, for the mentioned purposes, it seems unnecessary to acquire expensive supplements instead of infusions.pt_PT
dc.identifier.citationPereira, Carla; Barros, Lillian; Ferreira, Isabel C.F.R. (2014). Borututu, artichoke and milk thistle: chemical profiles, antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity. In 62th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA2014. Guimarãespt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12217
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectHepatotoxicitypt_PT
dc.subjectNutritional valuept_PT
dc.subjectChemical profilespt_PT
dc.titleBorututu, artichoke and milk thistle: chemical profiles, antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicitypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.title62th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research- GA2014pt_PT
person.familyNamePereira
person.familyNameBarros
person.familyNameFerreira
person.givenNameCarla
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier1415151
person.identifier469085
person.identifier144781
person.identifier.ciencia-idEF10-2739-2B70
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-0093-771X
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridK-1629-2016
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55627876424
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicatione07a8e12-52bb-47c5-bae7-41a5f648213b
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01

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