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Antiangiogenic compounds: well-established drugs versus emerging natural molecules

2018Journal article Open access
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dc.contributor.authorRibeiro, Andreia
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorDias, Madalena M.
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-01-29T10:00:00Z
dc.date.accessioned2018-01-29T10:39:24Z
dc.date.available2018-01-29T10:00:00Z
dc.date.available2018-01-29T10:39:24Z
dc.date.issued2018
dc.description.abstractAngiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesis-related pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs. Using natural compounds as potential angiogenesis modulators is thus a promising field of research, supporting the creation of novel therapies able to reduce the use of drugs and associated side effects. In this review, the current status of antiangiogenic drugs and the wide variety of natural extracts and molecules with antiangiogenic capacities, as well as the angiogenesis molecular pathways and therapeutic targets, are presented. Finally, the challenges that need to be overcome in order to increase the use of natural compounds for clinical purposes are discussed.pt_PT
dc.description.sponsorshipPOCI-01-0145-FEDER-006984 (LA LSRE-LCM), funded by FEDER, through POCI-COMPETE2020 and FCT; Project NORTE-01-0145- FEDER-000006, funded by NORTE2020 under the PT2020, through ERDF; FCT and ERDF under PT2020 for financial support to CIMO (UID/AGR/00690/2013). Andreia Ribeiro acknowledges her PhD fellowship funded by Project NORTE-08-5369-FSE-000028, supported by N2020, under PT2020, through ESF.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, Andreia; Abreu, Rui M.V.; Dias, Madalena M.; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2018). Antiangiogenic compounds: well-established drugs versus emerging natural molecules. Cancer Letters. ISSN 0304-3835. 415. p. 86-105
dc.identifier.doi10.1016/j.canlet.2017.12.006pt_PT
dc.identifier.issn0304-3835
dc.identifier.urihttp://hdl.handle.net/10198/15041
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.subjectAngiogenesis
dc.subjectMolecular targets
dc.subjectSynthetic drugs
dc.subjectNatural compounds
dc.titleAntiangiogenic compounds: well-established drugs versus emerging natural moleculesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.fundingStream5876
person.familyNameAbreu
person.familyNameBarreiro
person.familyNameFerreira
person.givenNameRui M.V.
person.givenNameFilomena
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id0F19-0DE2-12A2
person.identifier.ciencia-id3418-47D5-5746
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0002-6844-333X
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridL-9802-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id7003290613
person.identifier.scopus-author-id57188719717
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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