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Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”

dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorĆirić, Ana
dc.contributor.authorNikolić, Miloš
dc.contributor.authorFernandes, Ângela
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSoković, Marina
dc.contributor.authorVan Griensven, Leo J.L.D.
dc.date.accessioned2015-11-24T15:02:20Z
dc.date.available2015-11-24T15:02:20Z
dc.date.issued2015
dc.description.abstractChemical composition and biological properties of aqueous and ethanolic extracts of Inonotus obliquus (Pers.:Fr.) Pilat from different origins, i.e. of Finland, Russia, and Thailand, were studied. Concerning biological activity, antimicrobial, antiqourum, antioxidative, and antitumor and cytotoxic effects were tested. Oxalic acid was found as the main organic acid, with the highest amount in Russian aqueous extract. Gallic, protocatechuic and p-hydroxybenzoic acids were detected in all samples. I. obliquus extracts showed high antioxidant and antimicrobial activity. Extracts were tested at subMIC for anti-quorum sensing (AQS) activity in Pseudomonas aeruginosa and all of them showed definite AQS activity. The assays were done using twitching and swarming of bacterial cultures, as well as the amount of produced pyocyanin as QS parameters. All the extracts possessed good antitumor effect on four cells lines and did not show hepatotoxicity on porcine liver primary cells designed as PLP2. As the I. obliquus presence in Chaga conks is limited, further purification is necessary to draw quantitative conclusions. The presence of AQS activity in medicinal mushrooms suggests a broader anti-infectious disease protection than only immunomodulatory effects.pt_PT
dc.description.sponsorshipThe authors are grateful to Serbian Ministry of Education, Science and Technological Development for financial support (grant number 173032), to Foundation for Science and Technology (FCT, Portugal) and COMPETE/QREN/EU for financial support to CIMO strategic project PEst-OE/AGR/UI0690/2011, L. Barros contract, A. Fernandes (SFRH/BD/76019/2011) and R.C. Calhelha (SFRH/BPD/68344/2010) grants.pt_PT
dc.identifier10.1016/j.jep.2014.12.069
dc.identifier.citationGlamočlija, Jasmina; Ćirić, Ana; Nikolić, Miloš; Fernandes, Ângela; Barros, Lillian; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Soković, Marina; van Griensven, Leo J.L.D. (2015). Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”. Journal of Ethnopharmacology. ISSN 0378-8741. 162, p. 323-332pt_PT
dc.identifier.doi10.1016/j.jep.2014.12.069pt_PT
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/10198/12408
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - UI 690 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInonotus obliquuspt_PT
dc.subjectChemical characterizationpt_PT
dc.subjectAntioxidant propertiespt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectAntiquorum effectpt_PT
dc.subjectAntitumor activitypt_PT
dc.titleChemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F76019%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.endPage332pt_PT
oaire.citation.startPage323pt_PT
oaire.citation.titleJournal of Ethnopharmacologypt_PT
oaire.citation.volume162pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameFernandes
person.familyNameBarros
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameÂngela
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2015-0434-AE7C
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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