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Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.

2017Journal article Open access
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dc.contributor.authorJabeur, Inès
dc.contributor.authorMartins, Natália
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorAchour, Lotfi
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-30T15:00:33Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-30T15:00:33Z
dc.date.issued2017
dc.description.abstractNaturally-occurring phytochemicals have received pivotal attention in the last few years, due to the increasing evidence of biological activities. Thus, in the present study, the antioxidant, anti-inflammatory and antitumor potentials of hydroethanolic extracts rich in phenolic compounds obtained from Equisetum giganteum L. and Tilia platyphyllos Scop. were assessed and directly correlated with their content of phenolic compounds, by using HPLC-DAD-ESI/MS analysis. T. platyphyllos showed the higher bioactive potential, evaluated in terms of antioxidant (radical scavenging effects-105 µg mL -1 , reducing power-123 µg mL -1 , ß-carotene bleaching inhibition-167 µg mL -1 , and lipid peroxidation inhibition-56 µg mL -1 ), anti-inflammatory (225 µg mL -1 inhibited 50% of nitric oxide production) and antitumor (breast-224 µg mL -1 ; lung-247 µg mL -1 ; cervical-195 µg mL -1 and hepatocellular-173 µg mL -1 carcinoma cells) activity, without having cytotoxic effects ( > 400 µg mL -1 ). These biological properties were positively correlated with its content and composition of phenolic compounds. Flavonoid contents were markedly higher than the content of phenolic acids, in both samples, being respectively 50.4 mg g -1 and 11.65 mg g -1 for T. platyphyllos, and 21.7 mg g -1 and 4.98 mg g -1 for E. giganteum. Moreover, while in E. giganteum extract, kaempferol-O-glucoside-O-rutinoside was the most abundant flavonoid, in T. platyphyllos extract protocatechuic acid and (-)-epicatechin were the most abundant phenolic acid and flavonoid, respectively. In relation to their content of phenolic acids, protocatechuic and caffeic acids existed in higher abundance in T. platyphyllos and E. giganteum hydroethanolic extracts, respectively. However, it would be interesting to evaluate the in vivo efficacy of both plant extracts to unveil the involved modes of action and to establish effective therapeutic doses.pt_PT
dc.description.sponsorshipThe authors are grateful to Fundação para a Ciência e a Tecnologia (FCT, Portugal) for financial support to CIMO (Pest-OE/AGR/UI0690/2015) and to POCI-01-0145-FEDER- 006984 (LA LSRE-LCM) funded by ERDF through POCICOMPETE2020 and FCT. L. Barros and N. Martins thank FCT for their grants (SFRH/BPD/107855/2015 and SFRH/BD/87658/ 2012, respectively). The GIP-USAL is financially supported by the Spanish Government through the project AGL2015-64522- C2-2-R.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJabeur, Inés; Martins, Natália; Barros, Lillian; Calhelha, Ricardo C.; Vaz, Josiana; Achour, Lotfi; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2017). Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop. Food and Function. ISSN 2042-6496. 8, p. 975-984en_EN
dc.identifier.doi10.1039/c6fo01778apt_PT
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/15304
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relationAGL2015-64522-C2-2-R
dc.relationProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
dc.relationPLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
dc.titleContribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.en_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
oaire.awardTitlePLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F107855%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87658%2F2012/PT
person.familyNameJabeur
person.familyNameBarros
person.familyNameCalhelha
person.familyNameVaz
person.familyNameFerreira
person.givenNameInès
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameJosiana A.
person.givenNameIsabel C.F.R.
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person.identifier.orcid0000-0002-7485-3554
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-6989-1169
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id16305323200
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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