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Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. & Reut and Thymus vulgaris L. essential oils

2014Journal article Open access
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dc.contributor.authorNikolić, Miloš
dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorMarković, Tatjana
dc.contributor.authorMarković, Dejan
dc.contributor.authorGiweli, Abdulhmid A.M.
dc.contributor.authorSoković, Marina
dc.date.accessioned2014-04-24T09:01:40Z
dc.date.available2014-04-24T09:01:40Z
dc.date.issued2014
dc.description.abstractAromatic plant species of genus Thymus are important medicinal plants, highly recommended due to a range of therapeutic properties of their essential oils, commonly known as thyme oil: antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. The oil is also beneficial in boosting the immune system and helps to fight colds, flu, infectious diseases and chills. It is proved to be a urinary antiseptic, being very helpful for cystitis and urethritis. Scientific validation of traditional uses, and phytochemical and bioactivity evaluation of essential oils from Thymus serpyllum, Thymus algeriensis and Thymus vulgaris were performed. GC/MS analysis revealed thymol as a major component of T. algeriensis, T. vulgaris and T. serpyllum, with its contribution to the oil 56.0%, 48.9% and 38.5%, respectively. All three essential oils (EOs) exhibited a significant antimicrobial activity against all tested strains, the T. serpyllum oil being the most potent one (MIC 2.5–5 μg/mL, MBC 5–10 μg/mL; MIC 1–2 μg/mL, MFC 2–4 μg/mL). In addition, the T. serpyllum oil revealed the highest antioxidant activity in all conducted assays and it was the most effective one against all tested cell lines, presenting GI50 values of 7.02–52.69 μg/mL. Moreover, none of the EOs showed toxicity at tested concentrations (>400 μg/mL) for porcine liver primary cell culture. In addition to their well-known traditional use in food and cosmetics, the great potential of tested Thymus essential oils for application in oral diseases and anticancer treatments, encourage further investigation.por
dc.description.sponsorshipMinistry of Education, Science and Technological Development of Serbia for financial support (Grant № 173032). The authors are also grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support of research centre CIMO (PEst-OE/AGR/UI0690/2011). Â. Fernandes and R.C. Calhelha thank FCT, POPH-QREN and FSE for their grants (SFRH/BD/76019/2011 and SFRH/BPD/BPD/68344/2010, respectively).por
dc.identifier.citationNikolić, Miloš: Glamočlija, Jasmina; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Fernandes, Ângela; Marković, Tatjana; Marković, Dejan; Giweli, Abdulhamed; Sokovic, Marina (2014). Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. & Reut and Thymus vulgaris L. essential oils. Industrial Crops and Products. ISSN 0926-6690. 52, p. 183–190por
dc.identifier.doi10.1016/j.indcrop.2013.10.006
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/9429
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationPEst-OE/AGR/U10690/2011
dc.subjectT. serpyllumpor
dc.subjectT. algeriensispor
dc.subjectT. vulgarispor
dc.subjectEssential oilspor
dc.subjectChemical compositionpor
dc.subjectCytotoxic, antioxidantpor
dc.titleChemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. & Reut and Thymus vulgaris L. essential oilspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F76019%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.endPage190por
oaire.citation.startPage183por
oaire.citation.titleIndustrial Crops and Productspor
oaire.citation.volume52por
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameFerreira
person.familyNameCalhelha
person.familyNameFernandes
person.givenNameIsabel C.F.R.
person.givenNameRicardo C.
person.givenNameÂngela
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id2015-0434-AE7C
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-0157-9873
person.identifier.ridE-8500-2013
person.identifier.ridJ-2172-2014
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id6507978333
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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