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Phenolic profiling of Silybum marianum (L.) Gaertn (milk thistle) by HPLC-DAD-ESI/MS

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dc.contributor.authorPereira, Carla
dc.contributor.authorBarros, Lillian
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-11-03T12:36:59Z
dc.date.available2015-11-03T12:36:59Z
dc.date.issued2014
dc.description.abstractMilk thistle (Silybum marianum (L.) Gaertn., Asteraceae) is an annual to biennial herbaceous plant native to the Mediterranean basin. The main pharmacologically active constituents of mik thistle fruits are flavonoligans such as silybin A, silybin B, isosylibin A, isosylibin B. silychristin, isosilychristin, and silydianin [2]. and they possess antioxidant and hepatoprotective properties [1]. The aim of this study was to compare the phenolic profiles of milk thistle infusion and hydromethanolic extract with the aid of HPLC-DADESIIMS. Similar phenolic profiles were observed for the two preparations, with only quantitative differences between them. The infusion revealed a higher concentration in total phenolic compounds (5.57 mg/g) than the hydromethanolic extract (3.56 mg/g), with apigenin-7-O-glucuronide as the major compound in both preparations (3.14 mg/g in the infusion, and 0.58 mg/g in the hydromethanolic extract). Total flavonoids were higher in the infusion (4.66 mg/g), with apigenin-7-O-glucuronide, luteolin-7-O-glucuronide (1.17 mg/g), and apigenin-O-deoxyhexosyl-glucuronide (0.36 mg/g) as the main constituents. The hydromethanolic extract showed a higher content of total phenolic acids (1.65 mg/g), including 5-O-caffeolyquinic and protocatechuic acids (0.56 and 0.44 mg/g, respectively). Besides these phenolic acids, the hydromethanolic extract also revealed high levels of luteolin-7-O-glucuronide (0.58 mg/g).pt_PT
dc.identifier.citationPereira, Carla; Barros, Lillian; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2014). Phenolic profiling of Silybum marianum (L.) Gaertn (milk thistle) by HPLC-DAD-ESI/MS. In 62th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA2014. Guimarãespt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12251
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationStrategic Project - UI 690 - 2014
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhenolic compositionpt_PT
dc.subjectMilk thistlept_PT
dc.subjectHPLC-DAD-ESIIMSpt_PT
dc.titlePhenolic profiling of Silybum marianum (L.) Gaertn (milk thistle) by HPLC-DAD-ESI/MSpt_PT
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberPEst-OE/AGR/UI0690/2014
oaire.awardTitleStrategic Project - UI 690 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.citation.title62th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research- GA2014pt_PT
oaire.fundingStream5876
person.familyNamePereira
person.familyNameBarros
person.familyNameFerreira
person.givenNameCarla
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier1415151
person.identifier469085
person.identifier144781
person.identifier.ciencia-idEF10-2739-2B70
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-0093-771X
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridK-1629-2016
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55627876424
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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