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Bioactive metabolites from algae: occurrence, extraction techniques, functional properties, food applications and therapeutic prospects

datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorPereira, Cláudia S.G.P.
dc.contributor.authorCarpena, M.
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorSilva, Cristiana F.C.
dc.contributor.authorPrieto Lage, Miguel A.
dc.contributor.authorOliveira, Beatriz
dc.date.accessioned2026-01-15T16:22:49Z
dc.date.available2026-01-15T16:22:49Z
dc.date.issued2026
dc.description.abstractThis review critically summarizes the major algal-derived bioactive compounds, including phenolics compounds (e.g., phlorotannins, bromophenols, phenolic acids), sterols (e.g., fucosterol, beta-sitosterol), and polysaccharides (e. g., carrageenan, fucoidan, ulvan), as well as key pigments such as astaxanthin, beta-carotene, lutein, violaxanthin, zeaxanthin, and chlorophylls. In addition, state-of-the-art extraction technologies including supercritical fluid extraction, pressurized liquid extraction, ultrasound assisted, microwave assisted, surfactant assisted, and enzyme assisted extractions, and carbon dioxide-expanded liquids) were systematically compared considering key parameters such as yield, versatility, compound selectivity, extract quality, cost-effectiveness, technical complexity, operational conditions, and sustainability principles. Based on this comparative evaluation, ultrasound assisted extraction emerged as the most versatile among advanced technologies, same as enzyme assisted extraction within ulterior techniques. The potential incorporation of these bioactive compounds into novel algaebased food systems, either as functional ingredients or texturizing agents, was also discussed. Moreover, their relevance in alternative therapeutic applications was also highlighted, with a proof-of-concept focused on the antiviral potential of sulfated polysaccharides (carrageenan, fucoidan, and ulvan). Overall, algae-based ingredients were found to be promising biofunctional agents for innovative food products, nutraceutical formulations, and therapeutic alternatives.eng
dc.description.sponsorshipAuthors also thank the EU-FORA Fellowship Program (EUBA-EFSA-2023-ENREL-01-ALGAESAFE-GA14). JCMB acknowledges FCT for his contract (FCT-Tenure: 2023.11031.TENURE.023); CSGPP (2021.09490.BD) and MC (2024.05795.BD) thank FCT for their PhD grants.
dc.identifier.citationPereira, Claudia S.G.P.; Carpena, M.; Barreira, Joao C.M.; Silva, Cristiana F. C.; Prieto, M. A.; Oliveira, Beatriz (2026). Bioactive metabolites from algae: occurrence, extraction techniques, functional properties, food applications and therapeutic prospects. Future Foods. ISSN 2666-8335. 13, p. 1-21
dc.identifier.doi10.1016/j.fufo.2025.100866
dc.identifier.issn2666-8335
dc.identifier.urihttp://hdl.handle.net/10198/35497
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier BV
dc.relation.ispartofFuture Foods
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAlgae
dc.subjectBioactive compounds
dc.subjectExtraction technologies
dc.subjectBiofunctional applications
dc.titleBioactive metabolites from algae: occurrence, extraction techniques, functional properties, food applications and therapeutic prospectseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFuture Foods
oaire.citation.volume13
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBarreira
person.givenNameJoão C.M.
person.identifier.orcid0000-0003-1233-0990
person.identifier.ridD-8269-2013
person.identifier.scopus-author-id54895546900
relation.isAuthorOfPublication4629b12c-39b0-4da8-8b8d-6efba5cf2d81
relation.isAuthorOfPublication.latestForDiscovery4629b12c-39b0-4da8-8b8d-6efba5cf2d81

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