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Insights on the evolution of bacterial susceptibility exposed to multiple antibiotics: a triennial epidemiological study

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dc.contributor.authorAlves, Maria José
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorPimentel, Maria Helena
dc.contributor.authorPintado, Manuela
dc.date.accessioned2015-10-29T11:36:40Z
dc.date.available2015-10-29T11:36:40Z
dc.date.issued2014
dc.description.abstractIntroduction: The emergence and propagation of multi-resistant bacteria in the hospital environment have become serious epidemiological and therapeutic problems. It is essential to update data regarding the susceptibility to the most commonly used antibiotics in each hospital, allowing obtaining specific resistance patterns to define the antibiotic therapy. Objectives: This study aims to establish a profile of susceptibility vs. resistance for different microorganisms isolated during 3 years (2009-2011) using 3300 clinical isolates of different biological samples obtained from different hospital units belonging to Centro Hospitalar de Trás-os-Montes e Alto Douro (CHTMAD). Methods: Identification and susceptibility tests were done using microdilution plate method and results were submitted to principal component analysis (PCA). Results: Methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecium and coagulase negative Staphylococcus (CNS) seem to be the most concerning Gram positive microorganisms. For Gram negative species, despite the high resistance presented by Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBL) to b-lactamic antibiotics, imipenem is still a good therapeutic option, as well as fosfomycin (for urinary infection). Stenotrophomonas maltophilia, Pseudomonas aeruginosa MR and Acinetobacter baumannii, are progressively acquiring higher resistance to these antibiotics, mainly to imipenem, cotrimoxazol and even aminoglycosides (tobramycin and gentamycin). Conclusions: Overall, the developed resistance seems to be directly associated with antibiotics use and, therefore, studies centered in multi-resistance to antibiotics are crucial to establish dynamic protocols adequate to specific resistance vs. susceptibility profiles.pt_PT
dc.identifier.citationAlves, Maria José; Ferreira, Isabel C.F.R.; Barreira, João C.M.; Pimentel, Helena; Pintado, Manuela (2014). Insights on the evolution of bacterial susceptibility exposed to multiple antibiotics: a triennial epidemiological study. In 2nd World Congress of Health Research. Viseupt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12219
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMultidrug-resistant microorganismpt_PT
dc.subjectSurveillancept_PT
dc.titleInsights on the evolution of bacterial susceptibility exposed to multiple antibiotics: a triennial epidemiological studypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.title2nd World Congress of Health Researchpt_PT
person.familyNameAlves
person.familyNameFerreira
person.familyNameBarreira
person.familyNamePimentel
person.givenNameMaria José
person.givenNameIsabel C.F.R.
person.givenNameJoão C.M.
person.givenNameMaria Helena
person.identifier144781
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0002-0930-7469
person.identifier.ridM-6624-2016
person.identifier.ridE-8500-2013
person.identifier.ridD-8269-2013
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id54895546900
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication7850f8c2-8834-4d5a-b4a7-df482abd76d3
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication4629b12c-39b0-4da8-8b8d-6efba5cf2d81
relation.isAuthorOfPublication4fc182c0-1925-4c27-92c2-5a4bd06680c5
relation.isAuthorOfPublication.latestForDiscovery4629b12c-39b0-4da8-8b8d-6efba5cf2d81

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