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Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae

2023Conference object Open access
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dc.contributor.authorFilipe, Márcia Santos
dc.contributor.authorDominguez, Eva
dc.contributor.authorIsca, Vera
dc.contributor.authorPereira, Raquel
dc.contributor.authorMandim, Filipa
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorDiaz-Lanza, Ana María
dc.contributor.authorBarros, Lillian
dc.contributor.authorRijo, Patrícia
dc.date.accessioned2024-05-06T13:56:37Z
dc.date.available2024-05-06T13:56:37Z
dc.date.issued2023
dc.description.abstractPlectranthus genus (Lamiaceae) is known to be rich in bioactive abietane royleanone-type diterpenes, such as 6,7-dehydroxyroyleanone (1, Fig. 1), which have been previously found in P. madagascariensis (var. aliciae Codd). This abietane royleanone presents moderate to significant to cytoxic activity against several cancer cell lines. Moreover, 1 has one hydroxyl group suitable for deri- vatization that can be explored to enhance the cytotoxic activity of lead com- pound 1. Based on this, the aim of the present work is to explore the obtention of 1, from P. aliciae aliciae (Codd) van Jaarsv. & T.J.Edwards., a subspecies of P. madagascariensis to be further used in the preparation of new derivatives with enhanced biological activities.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFilipe, Márcia Santos; Dominguez, Eva; Isca, Vera; Pereira, Raquel; Mandim, Filipa; Calhelha, Ricardo C.; Diaz Lanza, Ana Maria; Barros, Lillian; Rijo, Patrícia (2023).Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae. Planta Médica. ISSN 0032-0943. 89:14, p. 1337pt_PT
dc.identifier.eissn1439-0221
dc.identifier.issn0032-0943
dc.identifier.urihttp://hdl.handle.net/10198/29718
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThiemept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleBiological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciaept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.issue14pt_PT
oaire.citation.titlePlanta Médicapt_PT
oaire.citation.volume89pt_PT
person.familyNameMandim
person.familyNameCalhelha
person.familyNameBarros
person.givenNameFilipa
person.givenNameRicardo C.
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationbcc274d4-7e6c-46a8-8e49-2752f9dbfbcd
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscoverybcc274d4-7e6c-46a8-8e49-2752f9dbfbcd

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