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Advisor(s)
Abstract(s)
The separation of enantiomers of la,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane (Sandoz epoxide) on
cellulose triacetate HPLC columns was investigated on the laboratory scale. The performance of the columns was
calculated by HEPT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities
were calculated from elution chromatographic experiments. Multi-component adsorption equilibrium isotherms
were calculated from single isotherms by using the ideal adsorbed solution (IAS) model. Simulation of continuous
chromatographic separation of the racemic mixture of Sandoz epoxide in a simulated moving bed was carried out
and the effect of mass transfer coefficient on process performance was analysed.
Description
Keywords
Chiral epoxide Chiral separation
Citation
Rodrigues, A.E.; Lu, Z.P.; Loureiro, J.M.; Pais, L.S. (1995). Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed. Journal of Chromatography A. ISSN 0021-9673. 702:1-2, p.223-231
Publisher
Elsevier