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Nutrients, Phytochemicals, and In Vitro Biological Activities of Goldenberry (Physalis peruviana L.) Fruit and Calyx

2025Journal article Open access
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datacite.subject.fosCiências Agrárias::Agricultura, Silvicultura e Pescas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorAñibarro-Ortega, Mikel
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPetrović, Jovana
dc.contributor.authorMandim, Filipa
dc.contributor.authorNúñez, Sonia
dc.contributor.authorSoković, Marina
dc.contributor.authorLópez, Víctor
dc.contributor.authorBarros, Lillian
dc.contributor.authorPinela, José
dc.date.accessioned2025-04-07T11:31:19Z
dc.date.available2025-04-07T11:31:19Z
dc.date.issued2025
dc.description.abstractThis study provides a comprehensive characterization of Physalis peruviana L., covering the nutritional composition of the fruit and the phytochemical profiles and in vitro bioactive properties of berry and calyx extracts. The fresh fruit stood out as a source of dietary fiber (5.16 g/100 g) and is low in fat (0.49 g/100 g). A 100-g serving also contained notable amounts of ascorbic acid (32.0 mg), tocopherols (2.34 mg), potassium (253 mg), phosphorus (45 mg), and magnesium (20 mg). HPLC-DAD-ESI/MS analysis tentatively identified five physalin derivatives and one withanolide in the fruit extract, which showed significant antiproliferative activity against human colorectal adenocarcinoma (Caco-2) and non-small-cell lung carcinoma (NCI-H460) cells. The calyx extracts contained three phenolic acids and four flavonoids, demonstrating high antioxidant activity through physiologically relevant cell-based assays, the ability to inhibit advanced glycation end products (AGEs) formation and nitric oxide production, and also antiproliferative properties. These findings highlight goldenberry as a nutrient-dense fruit rich in vitamins and functional compounds with potential health benefits, supporting its recognition as a “superfruit”. Furthermore, the fruit calyx emerged as a valuable source of bioactive secondary metabolites with potential applications in food and pharmaceutical industries and related sectors.eng
dc.description.sponsorshipWork was supported by national funds through FCT/MCTES (PIDDAC): CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020). National funding by FCT through the individual research grant (DOI: 10.54499/2020.06297.BD) of M.A.-O. and the scientific employment program contract with M.I.D. (DOI: 10.54499/CEECINST/00016/2018/CP1505/CT0004) and L.B. (DOI: 10.54499/CEECINST/00107/2021/CP2793/CT0002). F.M. acknowledges the post-doctoral grant (0112_TRANSCOLAB_PLUS_2_P) under the TransCoLab PLUS project through the Interreg VA Spain-Portugal (POCTEP) program. J. Petrović and M.S. are grateful to the Ministry of Science, Technological Development and Innovation (contract nos. 451–03–9/2021–14/200007). V.L. is grateful to San Jorge University for financial support through Proyecto Interno ID 2223025 and to the Government of Aragon for financial support from the Phyto-Pharm group (ref. B44_20R). The authors are also grateful to FEDER Cooperación Interreg VI A Espanha—Portugal (POCTEP) 2021–2027 for financial support through the project 0033_NET4FOOD_1_P.
dc.identifier.citationAñibarro Ortega, Mikel; Dias, Maria Inês; Petrović, Jovana; Mandim Pires, Ana Filipa; Núñez, Sonia; Soković, Marina; López, Víctor; Barros, Lillian; Pinela, José (2025). Nutrients, Phytochemicals, and In Vitro Biological Activities of Goldenberry (Physalis peruviana L.) Fruit and Calyx. Plants. ISSN 2223-7747. 14:3, p. 1-24
dc.identifier.doi10.3390/plants14030327
dc.identifier.issn2223-7747
dc.identifier.urihttp://hdl.handle.net/10198/34395
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationValorisation of steroidal compounds from Solanaceae crop by-products into novel nutraceutical ingredients
dc.relation.ispartofPlants
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNutritional composition
dc.subjectPolyphenols
dc.subjectAntioxidant activity
dc.subjectEnzyme inhibition capacity
dc.subjectAntidiabetic potential
dc.subjectAnti-inflammatory potential
dc.subjectAntimicrobial activity
dc.subjectAntiproliferative activity
dc.titleNutrients, Phytochemicals, and In Vitro Biological Activities of Goldenberry (Physalis peruviana L.) Fruit and Calyxeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleValorisation of steroidal compounds from Solanaceae crop by-products into novel nutraceutical ingredients
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.06297.BD/PT
oaire.citation.endPage24
oaire.citation.issue3
oaire.citation.startPage1
oaire.citation.titlePlants
oaire.citation.volume14
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAñibarro-Ortega
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person.familyNamePinela
person.givenNameMikel
person.givenNameMaria Inês
person.givenNameFilipa
person.givenNameLillian
person.givenNameJosé
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person.identifier.orcid0000-0002-2835-5079
person.identifier.orcid0000-0001-8744-7814
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person.identifier.orcid0000-0002-9050-5189
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person.identifier.ridM-8242-2013
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person.identifier.scopus-author-id54388787000
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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