Publication
Design, synthesis and preliminar antioxidant evaluation of new hydroxy- chromone and xanthone derivatives
| dc.contributor.author | Albuquerque, Hélio | |
| dc.contributor.author | Proença, Carina | |
| dc.contributor.author | Ribeiro, Daniela | |
| dc.contributor.author | Freitas, Marisa | |
| dc.contributor.author | Santos, Clementina M.M. | |
| dc.contributor.author | Fernandes, Eduarda | |
| dc.contributor.author | Silva, Artur | |
| dc.date.accessioned | 2019-01-09T11:28:10Z | |
| dc.date.available | 2019-01-09T11:28:10Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Chromone and xanthone derivativas are well-known for their outstanding antioxidant properties. ln an effort to develop new antioxidants with improved efficacy, here we cteveloped a new synthetic strategy to prepare hydroxylated chromones 3 and xanthones 4 with extended conjugated rr-systems. The synthetic strategy involved the aldolcondensation of 2-methylchromones 1 with cinnamaldehyde 2 to give chromones 3. Subsequent electrocyclization and oxidation of chromones 3 afforded xanthones 4 (Fig. 1 ). The scavenging activities of both derivativas 3 and 4 were addressed against both reactive oxygen species (ROS) and reactive nitrogen species (RNS). Ali tested compounds exhibited scavenger effects dependent on the concentration, with ICso values found in the micromolar range [1]. | pt_PT |
| dc.description.sponsorship | Sincere thanks are expressed to Faculdade de Farmácia da Universidade do Porto, Universidade de Aveiro, Instituto Politécnico de Bragança, Fundação para a Ciência e a Tecnologia (FCT, Portugal), European Union, QREN, FEDER and COMPETE funding UCIBIOREQUIMTE (FCT UID/Multi/04378/2013) and OOPNA (FCT UID/QUI/00062/2013) Research Units and also to the Portuguesa National NMR Network (RNRMN). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Albuquerque, Hélio; Proença, Carina; Ribeiro, Daniela; Freitas, Marisa; Santos, Clementina M.M.; Fernandes, Eduarda; Silva, Artur (2018). Design, synthesis and preliminar antioxidant evaluation of new hydroxy- chromone and xanthone derivatives. IN 28th European Colloquim on Heterocyclic Chemistry. Lecce, Italy | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10198/18357 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Antioxidant | pt_PT |
| dc.subject | Hydroxychromone | pt_PT |
| dc.subject | Xanthone derivativas | pt_PT |
| dc.title | Design, synthesis and preliminar antioxidant evaluation of new hydroxy- chromone and xanthone derivatives | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00062%2F2013/PT | |
| oaire.citation.conferencePlace | Lecce, Italy | pt_PT |
| oaire.citation.startPage | 46 | pt_PT |
| oaire.citation.title | 28th European Colloquim on Heterocyclic Chemistry | pt_PT |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | 5876 | |
| person.familyName | Santos | |
| person.givenName | Clementina M.M. | |
| person.identifier.ciencia-id | 9018-DB9C-C590 | |
| person.identifier.orcid | 0000-0003-4380-7990 | |
| person.identifier.scopus-author-id | 7201458663 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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