A comprehensive review on xanthone derivatives as α-glucosidase inhibitors

Santos, Clementina M.M.; Freitas, Marisa; Fernandes, Eduarda

Publication

A comprehensive review on xanthone derivatives as α-glucosidase inhibitors

2018Journal article

dc.contributor.author	Santos, Clementina M.M.
dc.contributor.author	Freitas, Marisa
dc.contributor.author	Fernandes, Eduarda
dc.date.accessioned	2019-01-09T11:11:43Z
dc.date.available	2019-01-09T11:11:43Z
dc.date.issued	2018
dc.description.abstract	α-Glucosidase plays an important role in carbohydrate metabolism and is therefore an attractive therapeutic target for the treatment of diabetes, obesity and other related complications. In the last two decades, considerable interest has been given to natural and synthetic xanthone derivatives in this field of research. Herein, a comprehensive review of the literature on xanthones as inhibitors of α-glucosidase activity, their mechanism of action, experimental procedures and structure-activity relationships have been reviewed for more than 280 analogs. With this overview we intend to motivate and challenge researchers (e.g. chemistry, biology, pharmaceutical and medicinal areas) for the design of novel xanthones as multipotent drugs and exploit the properties of this class of compounds in the management of diabetic complications.	pt_PT
dc.description.sponsorship	This work received financial support from the European Union (FEDER funds POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundação para a Ciência e Tecnologia and Ministério da Educação e Ciência) under the Partnership Agreement PT2020 UID/QUI/50006/2013; FCT UID/QUI/00062/2013, and “Programa Operacional Competitividade e Internacionalização” (COMPETE) (POCI- 01-0145-FEDER-029241), and under the framework of QREN (NORTE-01-0145-FEDER-000024). Thanks are also due to Faculdade de Farmácia da Universidade do Porto and Instituto Politécnico de Bragança.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Santos, Clementina M.M.; Freitas, Marisa; Fernandes, Eduarda (2018). A comprehensive review on xanthone derivatives as α-glucosidase inhibitors. European Journal of Medicinal Chemistry. ISSN 0223-5234. 157, p. 1460-1479	pt_PT
dc.identifier.doi	10.1016/j.ejmech.2018.07.073	pt_PT
dc.identifier.issn	0223-5234
dc.identifier.uri	http://hdl.handle.net/10198/18353
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Elsevier Masson	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Diabetes	pt_PT
dc.subject	a-Glucosidase	pt_PT
dc.subject	Inhibition	pt_PT
dc.subject	QSAR	pt_PT
dc.subject	Xanthone	pt_PT
dc.title	A comprehensive review on xanthone derivatives as α-glucosidase inhibitors	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardURI	info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00062%2F2013/PT
oaire.citation.endPage	1479	pt_PT
oaire.citation.startPage	1460	pt_PT
oaire.citation.title	European Journal of Medicinal Chemistry	pt_PT
oaire.citation.volume	157	pt_PT
oaire.fundingStream	5876
oaire.fundingStream	5876
person.familyName	Santos
person.givenName	Clementina M.M.
person.identifier.ciencia-id	9018-DB9C-C590
person.identifier.orcid	0000-0003-4380-7990
person.identifier.scopus-author-id	7201458663
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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