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Propensity for biofilm formation by clinical isolates from urinary tract infections: developing a multifactorial predictive model to improve the antibiotherapy

2014Journal article Open access
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dc.contributor.authorAlves, Maria José
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorCarvalho, Inês
dc.contributor.authorTrinta, Luís
dc.contributor.authorPereira, Liliana
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorPintado, Manuela
dc.date.accessioned2014-07-01T08:22:03Z
dc.date.available2014-07-01T08:22:03Z
dc.date.issued2014
dc.description.abstractA group of biofilm-producing bacteria isolated from patients with urinary tract infections was evaluated, identifying the main factors contributing to biofilm formation. Among the 156 isolates, 58 (37.2%) were biofilm producers. The bacterial species (P<0.001), together with patient's gender (P = 0.022), were the factors with the highest influence for biofilm production. There was also a strong correlation of catheterization with biofilm formation, despite being less significant (P = 0.070) than species or gender. In fact, some of the bacteria isolated were biofilm producers in all cases. With regard to resistance profile among bacterial isolates, β-lactam antibiotics presented the highest number of cases/percentages--ampicillin (32/55.2%), cephalothin (30/51.7%), amoxicillin/clavulanic acid (22/37.9%)--although the carbapenem group still represented a good therapeutic option (2/3.4%). Quinolones (nucleic acid synthesis inhibitors) also showed high resistance percentages. Furthermore, biofilm production clearly increases bacterial resistance. Almost half of the biofilm-producing bacteria showed resistance against at least three different groups of antibiotics. Bacterial resistance is often associated with catheterization. Accordingly, intrinsic (age and gender) and extrinsic (hospital unit, bacterial isolate and catheterization) factors were used to build a predictive model, by evaluating the contribution of each factor to biofilm production. In this way, it is possible to anticipate biofilm occurrence immediately after bacterial identification, allowing selection of a more effective antibiotic (among the susceptibility options suggested by the antibiogram) against biofilm-producing bacteria. This approach reduces the putative bacterial resistance during treatment, and the consequent need to adjust antibiotherapy.por
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT, Portugal) and COMPETE/QREN/EU for financial support to this work (strategic projects PEst-OE/AGR/UI0690/2011 and PEst-OE/EQB/LA0016/2011). They also thank to CHTMAD – Hospital Center of Trás-os-Montes e Alto Douro and Siemens for all the support. J.C.M. Barreira also thanks to FCT, POPH-QREN and FSE for his grant (SFRH/BPD/72802/2010)
dc.identifier.citationAlves, Maria José; Barreira, João C.M.; Carvalho, Inês; Trinta, Luís; Pereira, Liliana; Ferreira, Isabel C.F.R.; Pintado, Manuela (2014). Propensity for biofilm formation by clinical isolates from urinary tract infections: developing a multifactorial predictive model to improve the antibiotherapy. Journal of Medical Microbiology. ISSN 1473-5644. 63:3, p. 471-477por
dc.identifier.doi10.1099/jmm.0.071746-0
dc.identifier.issn1473-5644
dc.identifier.urihttp://hdl.handle.net/10198/9800
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - LA 16 - 2011-2012
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.titlePropensity for biofilm formation by clinical isolates from urinary tract infections: developing a multifactorial predictive model to improve the antibiotherapypor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.endPage477por
oaire.citation.startPage471por
oaire.citation.titleJournal of Medical Microbiologypor
oaire.citation.volume63por
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlves
person.familyNameBarreira
person.familyNamePereira
person.familyNameFerreira
person.givenNameMaria José
person.givenNameJoão C.M.
person.givenNameLiliana
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-idEF14-9663-7872
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0002-0211-6205
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-6624-2016
person.identifier.ridD-8269-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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