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Magnetoliposomes based on magnetic/plasmonic nanoparticles loaded with tricyclic lactones for combined cancer therapy

2021Journal article Open access
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dc.contributor.authorRio, Irina S.R.
dc.contributor.authorRodrigues, Ana Rita O.
dc.contributor.authorRodrigues, Juliana M.
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorAlmeida, Bernardo G.
dc.contributor.authorPires, Ana
dc.contributor.authorPereira, André M.
dc.contributor.authorAraújo, João Paulo
dc.contributor.authorCastanheira, Elisabete M.S.
dc.contributor.authorCoutinho, Paulo J.G.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-29T23:37:21Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-29T23:37:21Z
dc.date.issued2021
dc.description.abstractLiposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanoparticles was 26.7 nm for MnFe2 O4 with 5–7 nm gold nanospheres. The average size of the core/shell nanoparticles was 28.8 nm for the magnetic core and around 4 nm for the gold shell. Two new potential antitumor fluorescent drugs, tricyclic lactones derivatives of thienopyridine, were loaded in these nanosystems with very high encapsulation efficiencies (higher than 98%). Assays in human tumor cell lines demonstrate that the nanocarriers do not release the antitumor compounds in the absence of irradiation. Moreover, the nanosystems do not cause any effect on the growth of primary (non-tumor) cells (with or without irradiation). The drug-loaded systems containing the core/shell magnetic/plasmonic nanoparticles efficiently inhibit the growth of tumor cells when irradiated with red light, making them suitable for a triggered release promoted by irradiation.en_EN
dc.description.sponsorshipThis research was funded by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UIDB/04650/2020) and through the research project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020), financed by the European Fund of Regional Development (FEDER), COMPETE2020, and Portugal2020. I.S.R.R. acknowledges FCT for a research grant under CF-UM-UP Strategic Funding (UID/FIS/04650/2019) and a PhD grant (2020.04431.BD). J.M.R. acknowledges FCT, ESF (European Social Fund—North Portugal Regional Operational Program) and HCOP (Human Capital Operational Program) for a PhD grant (SFRH/BD/115844/2016). The APC was also financed by FCT.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationRio, Irina S.R.; Rodrigues, Ana Rita O.; Rodrigues, Juliana M.; Queiroz, Maria João R.P.; Calhelha, R. C.; Ferreira, Isabel C.F.R.; Almeida, Bernardo G.; Pires, Ana; Pereira, André M.; Araújo, João P.; Castanheira, Elisabete M.S.; Coutinho, Paulo J.G. (2021). Magnetoliposomes based on magnetic/plasmonic nanoparticles loaded with tricyclic lactones for combined cancer therapy. Pharmaceutics. ISSN 1999-4923. 13:11, p. 1-22en_EN
dc.identifier.doi10.3390/pharmaceutics13111905en_EN
dc.identifier.urihttp://hdl.handle.net/10198/23266
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationPhysics Center of Minho and Porto Universities
dc.relationPhysics Center of Minho and Porto Universities
dc.relationSynthesis of new potential biological active compounds based on thiophene fused N-heterocycle scaffolds using cross-couplings, C-H activation and intra/intermolecular cyclizations Título antigo: Synthesis of new potential biological active compounds based on thiophene fused N-heterocycle scaffolds using cross-couplings, C-H activation and intramolecular cyclizations
dc.subjectCombined cancer therapyen_EN
dc.subjectMagnetoliposomesen_EN
dc.subjectManganese ferrite/gold nanoparticlesen_EN
dc.subjectNew antitumor drugsen_EN
dc.subjectThienopy-ridine derivativesen_EN
dc.titleMagnetoliposomes based on magnetic/plasmonic nanoparticles loaded with tricyclic lactones for combined cancer therapyen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePhysics Center of Minho and Porto Universities
oaire.awardTitlePhysics Center of Minho and Porto Universities
oaire.awardTitleSynthesis of new potential biological active compounds based on thiophene fused N-heterocycle scaffolds using cross-couplings, C-H activation and intra/intermolecular cyclizations Título antigo: Synthesis of new potential biological active compounds based on thiophene fused N-heterocycle scaffolds using cross-couplings, C-H activation and intramolecular cyclizations
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04650%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQUI-QFI%2F28020%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FFIS%2F04650%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F115844%2F2016/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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