Synthesis of chromone-related pyrazole compounds

Santos, Clementina M.M.; Silva, Vera L.M.; Silva, Artur

Publication

Synthesis of chromone-related pyrazole compounds

2017Journal article

dc.contributor.author	Santos, Clementina M.M.
dc.contributor.author	Silva, Vera L.M.
dc.contributor.author	Silva, Artur
dc.date.accessioned	2020-01-21T16:30:50Z
dc.date.available	2020-01-21T16:30:50Z
dc.date.issued	2017
dc.description.abstract	Chromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacent-nitrogen-containing heterocycles, represent two important classes of biologically active compounds. Certain derivatives of these scaffolds play an important role in medicinal chemistry and have been extensively used as versatile building blocks in organic synthesis. In this context, we will discuss the most relevant advances on the chemistry that involves both chromone and pyrazole rings. The methods reviewed include the synthesis of chromone-pyrazole dyads, synthesis of chromone-pyrazole-fused compounds, and chromones as starting materials in the synthesis of 3(5)-(2-hydroxyaryl)pyrazoles, among others. This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century.	pt_PT
dc.description.sponsorship	Thanks are due to University of Aveiro and FCT/MEC for the financial support of the QOPNA research unit (FCT UID/QUI/00062/2013) and CIQ-UP, University of Porto (POCI-01-0145-FEDER-006980; FCT: UID/QUI/00081/2013) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, as well as to the Polytechnic Institute of Bragança. V.L.M.S. is grateful to FCT for her grant (SFRH/BPD/108807/2015), in the ambit of “QREN e POCH e Tipologia 4.1 e Formação Avançada”, co-sponsored by FSE and by national funds of MCTES.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Santos, Clementina M.M.; Silva, Vera L.M.; Silva, Artur (2017). Synthesis of chromone-related pyrazole compounds. Molecules. ISSN 1420-3049. 22:10, p. 1-47	pt_PT
dc.identifier.doi	10.3390/molecules22101665	pt_PT
dc.identifier.issn	1420-3049
dc.identifier.uri	http://hdl.handle.net/10198/20460
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	pt_PT
dc.subject	Antineoplastic agents	pt_PT
dc.subject	Chromones	pt_PT
dc.subject	Drug design	pt_PT
dc.subject	Humans	pt_PT
dc.subject	Molecular structure	pt_PT
dc.subject	Pyrazoles	pt_PT
dc.subject	Structure-activity relationship	pt_PT
dc.title	Synthesis of chromone-related pyrazole compounds	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardURI	info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00062%2F2013/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00081%2F2013/PT
oaire.citation.issue	10	pt_PT
oaire.citation.title	Molecules	pt_PT
oaire.citation.volume	22	pt_PT
oaire.fundingStream	5876
oaire.fundingStream	5876
person.familyName	Santos
person.givenName	Clementina M.M.
person.identifier.ciencia-id	9018-DB9C-C590
person.identifier.orcid	0000-0003-4380-7990
person.identifier.scopus-author-id	7201458663
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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