Publication
Amanita phalloides poisoning: Mechanisms of toxicity and treatment
| dc.contributor.author | Garcia, Juliana | |
| dc.contributor.author | Costa, Vera M. | |
| dc.contributor.author | Carvalho, Alexandra T.P. | |
| dc.contributor.author | Baptista, Paula | |
| dc.contributor.author | Pinho, P. Guedes de | |
| dc.contributor.author | Bastos, Maria de Lourdes | |
| dc.contributor.author | Carvalho, Félix | |
| dc.date.accessioned | 2018-06-18T10:34:18Z | |
| dc.date.available | 2018-06-18T10:34:18Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Amanita phalloides, also known as 'death cap', is one of the most poisonous mushrooms, being involved in the majority of human fatal cases of mushroom poisoning worldwide. This species contains three main groups of toxins: amatoxins, phallotoxins, and virotoxins. From these, amatoxins, especially α-amanitin, are the main responsible for the toxic effects in humans. It is recognized that α-amanitin inhibits RNA polymerase II, causing protein deficit and ultimately cell death, although other mechanisms are thought to be involved. The liver is the main target organ of toxicity, but other organs are also affected, especially the kidneys. Intoxication symptoms usually appear after a latent period and may include gastrointestinal disorders followed by jaundice, seizures, and coma, culminating in death. Therapy consists in supportive measures, gastric decontamination, drug therapy and, ultimately, liver transplantation if clinical condition worsens. The discovery of an effective antidote is still a major unsolved issue. The present paper examines the clinical toxicology of A. phalloides, providing the currently available information on the mechanisms of toxicityinvolved and on the current knowledge on the treatment prescribed against this type of mushrooms. Antidotal perspectives will be raised as to set the pace to new and improved therapy against these mushrooms. | pt_PT |
| dc.description.sponsorship | This work was supported by the Fundação para a Ciência e Tecnologia (FCT ) – project PTDC/DTPFTO/4973/2014 – and the European Union (FEDER funds through COMPETE) and National Funds (FCT, Fundação para a Ciência e Tecnologia) through project Pest-C/EQB/LA0006/2013. Juliana Garcia and Vera Marisa Costa thank FCT for their PhD grant (SFRH/BD/74979/2010) and Post-doc grants (SFRH/BPD/63746/2009 and SFRH/BPD/110001/2015), respectively. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Garcia, Juliana; Costa, Vera M.; Carvalho, Alexandra; Baptista, Paula; Pinho, Paula Guedes de; Bastos, Maria de Lourdes; Carvalho, Félix (2015). Amanita phalloides poisoning: Mechanisms of toxicity and treatment. Food and Chemical Toxicology. ISSN 0278-6915. 86, p. 41-55 | pt_PT |
| dc.identifier.doi | 10.1016/j.fct.2015.09.008 | pt_PT |
| dc.identifier.issn | 0278-6915 | |
| dc.identifier.uri | http://hdl.handle.net/10198/17717 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation | PTDC/DTPFTO/4973/2014 | pt_PT |
| dc.relation | Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs New early putative biomarkers of cardiac damage for an earlier therapeutic approach | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Amanita phalloides | pt_PT |
| dc.subject | Amatoxins | pt_PT |
| dc.subject | RNA polymerase II | pt_PT |
| dc.subject | Liver | pt_PT |
| dc.subject | Kidney | pt_PT |
| dc.subject | Therapy | pt_PT |
| dc.title | Amanita phalloides poisoning: Mechanisms of toxicity and treatment | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs New early putative biomarkers of cardiac damage for an earlier therapeutic approach | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F74979%2F2010/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F63746%2F2009/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F110001%2F2015/PT | |
| oaire.citation.endPage | 55 | pt_PT |
| oaire.citation.startPage | 41 | pt_PT |
| oaire.citation.title | Food and Chemical Toxicology | pt_PT |
| oaire.citation.volume | 86 | pt_PT |
| oaire.fundingStream | SFRH | |
| oaire.fundingStream | SFRH | |
| person.familyName | Baptista | |
| person.givenName | Paula | |
| person.identifier.ciencia-id | 7D11-FE1E-CD0F | |
| person.identifier.orcid | 0000-0001-6331-3731 | |
| person.identifier.scopus-author-id | 14051688000 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 3f35226a-b17a-4f7d-8da1-3297105cbfe9 | |
| relation.isAuthorOfPublication.latestForDiscovery | 3f35226a-b17a-4f7d-8da1-3297105cbfe9 | |
| relation.isProjectOfPublication | 3140ff16-4042-4a9f-bf62-fa6a3fea5229 | |
| relation.isProjectOfPublication | 4d744214-5f4e-40e4-b20f-f42539a376b3 | |
| relation.isProjectOfPublication | 651140d2-5561-4ce0-abac-bc3e5b2980cc | |
| relation.isProjectOfPublication.latestForDiscovery | 4d744214-5f4e-40e4-b20f-f42539a376b3 |