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Biochemistry of secondary metabolism of fungi

2023Book part Restricted access
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dc.contributor.authorPascoalino, Liege
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.contributor.authorReis, Filipa S.
dc.date.accessioned2024-01-03T10:11:38Z
dc.date.available2024-01-03T10:11:38Z
dc.date.issued2023
dc.description.abstractFungi, eukaryotic organisms with a kingdom of their own, include microorganisms from moulds and yeasts to the most known and appreciated mushrooms. The incredible biodiversity of these organisms is not limited to their morphology but is reflected in their chemistry, namely in the variety of compounds they produce. Therefore, like other living beings, fungi can be an excellent source of bioactive compounds. Although they may be primary metabolites, fungal bioactive compounds are mainly produced through secondary metabolism. These compounds have an essential role in the fungal survival and adaptation to almost all habitats on earth. Besides, they can also exert beneficial effects on human health, such as antioxidant, antimicrobial, anti-UV radiation, or even anti-inflammatory or antitumor activity. Given the wide bioactivity of the molecules produced, fungi have become, over time, an exciting source of compounds with possible application in various industries, including the food, pharmaceutical, or cosmetics industries. Fungal secondary metabolites are mainly produced via acetyl-CoA and via the shikimate pathway. Even though it is possible to find in the literature some different classifications regarding secondary metabolites of fungi, in this manuscript, we define polyketides, non-ribosomal peptides, terpenoids, and indole alkaloids as the main structural classes. The present chapter will present a brief introduction to fungal secondary metabolism, including some examples of the most well-known compounds and their principal functions in ecosystems. The biosynthetic pathways of the main classes of fungal secondary metabolites will also be depicted.pt_PT
dc.description.sponsorshipFCT, Portugal for financial support through national funds FCT/MCTES to the CIMO (UIDB/00690/2020), and the Bio Based Industries Joint Undertaking (JU) under the grant agreement No 888003 UP4HEALTH Project (H2020-BBI-JTI-2019), whom the author F.S. Reis thanks for her contract. L. Barros thank the national funding by FCT, P.I., through the institutional scientific employment program-contract for her contract. T. Oludemi and T.C.S.P. Pires thank the MICINN for their Juan de la Cierva Formación contract (FJC2019-042549-I and FJC2020-045405-I, respectively). The authors also thank the FEDER-Interreg España-Portugal programme through the project TRANSCoLAB 0612_TRANS_CO_LAB_2_P.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPascoalino, Liege; Pires, Tânia C.S.P.; Taofiq, Oludemi; Ferreira, Isabel C.F.R.; Barros, Lillian; Reis, Filipa S. (2023). Biochemistry of secondary metabolism of fungi. Natural Secondary Metabolites: From Nature, Through Science, to Industry. Cham: Springer Nature. p. 437-474. ISBN 978-3-031-18586-1pt_PT
dc.identifier.doi10.1007/978-3-031-18587-8_13pt_PT
dc.identifier.isbn978-3-031-18586-1
dc.identifier.isbn978-3-031-18587-8 (eBook)
dc.identifier.urihttp://hdl.handle.net/10198/29030
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationMountain Research Center
dc.relationSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectBiosynthetic pathwayspt_PT
dc.subjectFungipt_PT
dc.subjectSecondary metabolitespt_PT
dc.titleBiochemistry of secondary metabolism of fungipt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/888003/EU
oaire.citation.endPage474pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage437pt_PT
oaire.citation.titleNatural Secondary Metabolites: From Nature, Through Science, to Industrypt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamH2020
person.familyNamePascoalino
person.familyNamePires
person.familyNameFerreira
person.familyNameBarros
person.familyNameReis
person.givenNameLiege
person.givenNameTânia C.S.P.
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.givenNameFilipa S.
person.identifier2118829
person.identifier144781
person.identifier469085
person.identifier.ciencia-idA314-490A-7952
person.identifier.ciencia-id321E-2D96-00CA
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.orcid0000-0001-9855-6450
person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-9159-0530
person.identifier.ridQ-2842-2018
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.ridI-2093-2013
person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36982144400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
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