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Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report

2015Journal article Open access
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dc.contributor.authorGarcia, Juliana
dc.contributor.authorCosta, Vera M.
dc.contributor.authorCosta, Ana Elisa
dc.contributor.authorAndrade, Sérgio
dc.contributor.authorCarneiro, Ana Cristina
dc.contributor.authorConceição, Filipe
dc.contributor.authorPaiva, José Artur
dc.contributor.authorPinho, P. Guedes de
dc.contributor.authorBaptista, Paula
dc.contributor.authorBastos, Maria de Lourdes
dc.contributor.authorCarvalho, Félix
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2018-03-01T16:04:52Z
dc.date.accessioned2018-03-05T09:18:40Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2018-03-01T16:04:52Z
dc.date.available2018-03-05T09:18:40Z
dc.date.issued2015
dc.description.abstractMushroom poisonings occur when ingestion of wild mushrooms containing toxins takes place, placing the consumers at life-threatening risk. In the present case report, an unusual multiple poisoning with isoxazoles- and amatoxins-containing mushrooms in a context of altered mental state and poorly controlled hypertension is presented. A 68-year-old female was presented to São João hospital (Portugal) with complaints of extreme dizziness, hallucinations, vertigo and imbalance, 3 h after consuming a stew of wild mushrooms. The first observations revealed altered mental state and elevated blood pressure. The examination of cooked mushroom fragments allowed a preliminary identification of Amanita pantherina. Gas chromatography-mass spectrometry (GC-MS) showed the presence of muscimol in urine. Moreover, through high-performance liquid chromatography-ultraviolet detection (HPLC-UV) analysis of the gastric juice, the presence of α-amanitin was found, showing that amatoxins-containing mushrooms were also included in the stew. After 4 days of supportive treatment, activated charcoal, silybin and N-acetylcysteine, the patient recovered being discharged 10 days post-ingestion with no organ complications. The prompt and appropriate therapy protocol for life-threatening amatoxins toxicity probably saved the patient's life as oral absorption was decreased and also supportive care was immediately started.en_EN
dc.description.sponsorshipThis work received financial support from the European Union (FEDER funds through COMPETE) and National Funds (FCT, Fundação para a Ciência e Tecnologia) through project Pest-C/EQB/LA0006/2013. Juliana Garcia and Vera Marisa Costa thank FCT e Foundation for Science and Technology e for their PhD grant (SFRH/BD/74979/2010) and Post-doc grant (SFRH/BPD/63746/2009), respectively.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGarcia, Juliana; Costa, Vera M.; Costa, Ana Elisa; Andrade, Sérgio; Carneiro, Ana Cristina; Conceição, Filipe; Paiva, José Artur; De Pinho, Paula Guedes; Baptista, Paula; De Lourdes Bastos, Maria; Carvalho, Félix (2015). Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report. Toxicon. ISSN 0041-0101. 103, p. 55-59en_EN
dc.identifier.doi10.1016/j.toxicon.2015.06.012en_EN
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10198/16113
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectAmanita pantherinaen_EN
dc.subjectAmanita phalloidesen_EN
dc.subjectAmatoxinsen_EN
dc.subjectIntoxicationen_EN
dc.subjectIsoxazolesen_EN
dc.subjectWild mushroomsen_EN
dc.titleCo-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case reporten_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FEQB%2FLA0006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F74979%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F63746%2F2009/PT
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameBaptista
person.givenNamePaula
person.identifier.ciencia-id7D11-FE1E-CD0F
person.identifier.orcid0000-0001-6331-3731
person.identifier.scopus-author-id14051688000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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relation.isAuthorOfPublication.latestForDiscovery3f35226a-b17a-4f7d-8da1-3297105cbfe9
relation.isProjectOfPublicationf7e58456-fee7-485f-8b49-d2c240945602
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relation.isProjectOfPublication.latestForDiscovery3140ff16-4042-4a9f-bf62-fa6a3fea5229

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